ArticleBMC genetics2010
Genome-wide linkage scan for loci associated with epilepsy in Belgian shepherd dogs.
Article in BMC genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Genome-wide association study of idiopathic epilepsy in the Italian Spinone dog breed.PloS one · 2025Pooled it
- Assessment of genetic diversity using microsatellite markers to compare donkeys (Equus asinus) with horses (Equus caballus).Animal bioscience · 2021Article
- International Veterinary Epilepsy Task Force's current understanding of idiopathic epilepsy of genetic or suspected genetic origin in purebred dogs.BMC veterinary research · 2015Article
- International veterinary epilepsy task force consensus report on epilepsy definition, classification and terminology in companion animals.BMC veterinary research · 2015Article
- Identification of a common risk haplotype for canine idiopathic epilepsy in the ADAM23 gene.BMC genomics · 2015Article
- Molecular genetic diversity of the Gyeongju Donggyeong dog in Korea.The Journal of veterinary medical science · 2014Article
- Article
- Canine epilepsy genetics.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Review
- Article
- Candidate genes for idiopathic epilepsy in four dog breeds.BMC genetics · 2011Article
- Article
- Gene polymorphisms and their role in epilepsy treatment and prognosis.Naunyn-Schmiedeberg's archives of pharmacology · 2010Review
- Clinical characterization of epilepsy of unknown cause in cats.Journal of veterinary internal medicineArticle
- LGI Proteins and Epilepsy in Human and Animals.Journal of veterinary internal medicineReview
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIdiopathic epilepsy in the Belgian shepherd dog is known to have a substantial genetic component. The objective of this study was to identify genomic regions associated with the expression of generalized seizures in the Belgian Tervuren and Sheepdog.
resultsDNA from 366 dogs, of which 74 were classified as epileptic, representing two extended families were subjected to a genome-wide linkage scan using 410 microsatellite markers yielding informative coverage averaging 5.95 +/- 0.21 Mb. Though previous studies based on pedigree analyses proposed a major gene of influence, the present study demonstrated the trait to be highly polygenic. Studies of complex disorders in humans indicate that a liberal composite evaluation of genetic linkage is needed to identify underlying quantitative trait loci (QTLs). Four chromosomes yielded tentative linkage based upon LOD scores in excess of 1.0. Possible QTLs within these regions were supported also by analyses of multipoint linkage, allele frequency, TDT, and transmission of haplotype blocks.
conclusionsTaken together the data tentatively indicate six QTLs, three on CFA 2, and one on each of CFA 6, 12, and 37, that support fine mapping for mutations associated with epilepsy in the Belgian shepherd. The study also underscores the complexity of genomic linkage studies for polygenic disorders.
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