ArticleCellular and molecular life sciences : CMLS2010
Blocking of melatonin synthesis and MT(1) receptor impairs the activation of Jurkat T cells.
Article in Cellular and molecular life sciences : CMLS, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed, 34 citations in OpenAlex.
- Influence of Different Light Spectra on Melatonin Synthesis by the Pineal Gland and Influence on the Immune System in Chickens.Animals : an open access journal from MDPI · 2023Review
- Mechanism of action and promising clinical application of melatonin from a dermatological perspective.Journal of translational autoimmunity · 2023Article
- Circadian Rhythms and Melatonin Metabolism in Patients With Disorders of Gut-Brain Interactions.Frontiers in neuroscience · 2022Review
- Melatonin and Cancer: A Polyhedral Network Where the Source Matters.Antioxidants (Basel, Switzerland) · 2021Review
- A Green and Blue Monochromatic Light Combination Therapy Reduces Oxidative Stress and Enhances B-Lymphocyte Proliferation through Promoting Melatonin Secretion.Oxidative medicine and cellular longevity · 2021Article
- Melatonin transport into mitochondria.Cellular and molecular life sciences : CMLS · 2017Review
- Dietary Sources and Bioactivities of Melatonin.Nutrients · 2017Review
- Update on melatonin receptors: IUPHAR Review 20.British journal of pharmacology · 2016Review
- Melatonin, but not melatonin receptor agonists Neu-P11 and Neu-P67, attenuates TNBS-induced colitis in mice.Naunyn-Schmiedeberg's archives of pharmacology · 2016Article
- Melatoninergic System in Parkinson's Disease: From Neuroprotection to the Management of Motor and Nonmotor Symptoms.Oxidative medicine and cellular longevity · 2016Review
- Selective protection of the cerebellum against intracerebroventricular LPS is mediated by local melatonin synthesis.Brain structure & function · 2015Article
- Melatonin: buffering the immune system.International journal of molecular sciences · 2013Review
- Vaccination prepartum enhances the beneficial effects of melatonin on the immune response and reduces platelet responsiveness in sheep.BMC veterinary research · 2012Article
- Distribution, function and physiological role of melatonin in the lower gut.World journal of gastroenterology · 2011Review
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Melatonin has been proposed as regulating the immune system by affecting cytokine production in immunocompetent cells, enhancing the production of several T helper (Th)1 cytokines. To further investigate the melatonin's role in IL-2/IL-2R system, we established an inducible T-REx expression system in Jurkat cells in which the protein levels of HIOMT enzyme or MT(1) receptor were significantly down-regulated upon tetracycline incubation. We found that T-REx Jurkat cells with lower levels of HIOMT activity, and consequently lower content of endogenous melatonin, showed IL-2 production decrease after activation with lectin. Likewise, tetracycline-inducible stable cell line expressing MT(1) antisense produced decreased amounts of IL-2 (mRNA and protein levels) after stimulation. Moreover, in T-Rex-MT(1) cells incubated with tetracycline, a sub-optimal PHA dose failed to induce the early activation marker CD25 on the cell surface. The results shown here support the relevance of endogenous melatonin and its signaling in T cell activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.