Evidence map›Paper›PMID 20440281›Full record

ReviewNature reviews. Gastroenterology & hepatology2010

Gastric MALT lymphoma: a model of chronic inflammation-induced tumor development.

Xavier Sagaert, Eric Van Cutsem, Gert De Hertogh, Karel Geboes, Thomas Tousseyn

Open access · bronzeAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Gastroenterology & hepatology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 144 citations in OpenAlex.

  1. Review
  2. NLRC5-Deficient Macrophages Promote a Tumor-Permissive Phenotype via AXL- and MERTK-Mediated Efferocytosis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  3. Endoscopic Evaluation of a Gastric Mass Mimicking a Subepithelial Tumor.The Korean journal of helicobacter and upper gastrointestinal research · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Update on the pathogenesis and clinical management ofWorld journal of gastrointestinal pathophysiology · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Role of non-World journal of gastroenterology · 2023
    Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Xavier SagaertDepartment of Pathology, University Hospitals of K. U. Leuven, Minderbroederstraat 12, B-3000 Leuven, Belgium. xavier.sagaert@uz.kuleuven.ac.be
Eric Van Cutsem
Gert De Hertogh
Karel Geboes
Thomas Tousseyn
KU Leuven · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mucosa-associated lymphoid tissue (MALT) lymphoma, or extranodal marginal zone lymphoma of MALT, is an indolent B-cell non-Hodgkin lymphoma arising in lymphoid infiltrates that are induced by chronic inflammation in extranodal sites. The stomach is the most commonly affected organ, in which MALT lymphoma pathogenesis is clearly associated with Helicobacter pylori gastroduodenitis. Gastric MALT lymphoma has attracted attention because of the involvement of genetic aberrations in the nuclear factor kappaB (NFkappaB) pathway, one of the most investigated pathways in the fields of immunology and oncology. This Review presents gastric MALT lymphoma as an outstanding example of the close pathogenetic link between chronic inflammation and tumor development, and describes how this information can be integrated into daily clinical practice. Gastric MALT lymphoma is considered one of the best models of how genetic events lead to oncogenesis, determine tumor biology, dictate clinical behavior and represent viable therapeutic targets. Moreover, in view of the association of gastric MALT lymphoma with dysregulation of the NFkappaB pathway, this signaling pathway will be discussed in depth in both normal and pathological conditions, highlighting strategies to identify new therapeutic targets in this lymphoma.

Indexed as

Baculoviral IAP Repeat-Containing 3 ProteinCell Transformation, NeoplasticDisease ProgressionForkhead Transcription FactorsGastric MucosaGene Expression Regulation, NeoplasticHelicobacter InfectionsHelicobacter pyloriHumansImmunohistochemistryInhibitor of Apoptosis ProteinsLymphoma, B-Cell, Marginal ZoneLymphoma, Large B-Cell, DiffuseNF-kappa BOncogene Proteins, FusionRepressor ProteinsBaculoviral IAP Repeat-Containing 3 ProteinBIRC3 protein, humanForkhead Transcription FactorsFOXP1 protein, humanInhibitor of Apoptosis ProteinsNF-kappa BOncogene Proteins, FusionRELB protein, humanRepressor ProteinsTranscription Factor RelBUbiquitin-Protein Ligases

Identifiers

PMID20440281
OpenAlexW2021491719

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.