ArticleLaboratory investigation; a journal of technical methods and pathology2010
Hepatic stellate cells' involvement in progenitor-mediated liver regeneration.
Article in Laboratory investigation; a journal of technical methods and pathology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 71 citations in OpenAlex.
- Investigating the role of Wnt3a and Wnt5a as critical factors of hepatic stellate cell activation in acute toxicant-induced liver injury.Cell biology and toxicology · 2024Article
- Granulocyte colony-stimulating factor reduces biliary fibrosis and ductular reaction in a mouse model of chronic cholestasis.Liver research (Beijing, China) · 2023Article
- Targeting the Hepatic Microenvironment to Improve Ischemia/Reperfusion Injury: New Insights into the Immune and Metabolic Compartments.Aging and disease · 2022Review
- The Effects of Growth Factors and Cytokines on Hepatic Regeneration: A Systematic Review.Cureus · 2022Review
- Hepatic stellate cells in physiology and pathology.The Journal of physiology · 2022Review
- Role of Immune Cells in Biliary Repair.Frontiers in immunology · 2022Review
- Liver regeneration biology: Implications for liver tumour therapies.World journal of clinical oncology · 2021Review
- Dynamic cell contacts between periportal mesenchyme and ductal epithelium act as a rheostat for liver cell proliferation.Cell stem cell · 2021Article
- Hepatic Stellate Cell Regulation of Liver Regeneration and Repair.Hepatology communications · 2021Review
- Hepatic stellate cells contribute to liver regeneration through galectins in hepatic stem cell niche.Stem cell research & therapy · 2020Article
- Myofibroblast induces hepatocyte-to-ductal metaplasia via laminin-ɑvβ6 integrin in liver fibrosis.Cell death & disease · 2020Article
- Fibrotic liver has prompt recovery after ischemia-reperfusion injury.American journal of physiology. Gastrointestinal and liver physiology · 2020Article
- TGF-β1 signaling activates hepatic stellate cells through Notch pathway.Cytotechnology · 2019Article
- Ductular Reaction in Liver Diseases: Pathological Mechanisms and Translational Significances.Hepatology (Baltimore, Md.) · 2019Review
- Article
- The diversity and plasticity of adult hepatic progenitor cells and their niche.Liver international : official journal of the International Association for the Study of the Liver · 2017Review
- Liver progenitor cells-mediated liver regeneration in liver cirrhosis.Hepatology international · 2016Review
- Immunohistochemical study of hepatic fibropoiesis associated with canine visceral leishmaniasis.International journal of experimental pathology · 2016Article
- Early activated hepatic stellate cell-derived molecules reverse acute hepatic injury.World journal of gastroenterology · 2015Article
- Hepatic progenitor cells in canine and feline medicine: potential for regenerative strategies.BMC veterinary research · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Earlier studies conducted by our laboratory have shown that suppression of transforming growth factor-beta (TGFbeta)-mediated upregulation of connective tissue growth factor (CTGF) by iloprost resulted in a greatly diminished oval cell response to 2-acetylaminofluorene/partial hepatectomy (2AAF/PH) in rats. We hypothesized that this effect is due to decreased activation of hepatic stellate cells. To test this hypothesis, we maintained rats on a diet supplemented with 2% L-cysteine as a means of inhibiting stellate cell activation during the oval cell response to 2AAF/PH. In vitro experiments show that L-cysteine did, indeed, prevent the activation of stellate cells while exerting no direct effect on oval cells. Desmin immunostaining of liver sections from 2AAF/PH animals indicated that maintenance on the L-cysteine diet resulted in an 11.1-fold decrease in the number of activated stellate cells within the periportal zones. The total number of cells proliferating in the periportal zones of livers from animals treated with L-cysteine was drastically reduced. Further analyses showed a greater than fourfold decrease in the magnitude of the oval cell response in animals maintained on the L-cysteine diet as determined by immunostaining for both OV6 and alpha-fetoprotein (AFP). Global liver expression of AFP as measured by real-time PCR was shown to be decreased 4.7-fold in the L-cysteine-treated animals. These data indicate that the activation of hepatic stellate cells is required for an appropriate oval cell response to 2AAF/PH.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.