ArticleGenetics2010
Genome-wide association studies and the problem of relatedness among advanced intercross lines and other highly recombinant populations.
Article in Genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 2 syntheses or guidelines pooled it, 106 citations in OpenAlex.
- Genetic characterization of outbred Sprague Dawley rats and utility for genome-wide association studies.PLoS genetics · 2022Pooled it
- Independent evolution toward larger body size in the distinctive Faroe Island mice.G3 (Bethesda, Md.) · 2021Pooled it
- Genome-wide association analysis of resistance to frogeye leaf spot China race 7 in soybean based on high-throughput sequencing.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Multi-Omic Approaches to Identify Genetic Factors in Metabolic Syndrome.Comprehensive Physiology · 2021Article
- Accurate, ultra-low coverage genome reconstruction and association studies in Hybrid Swarm mapping populations.G3 (Bethesda, Md.) · 2021Article
- Multiple Loci Control Variation in Plasticity to Foliar Shade Throughout Development inG3 (Bethesda, Md.) · 2020Article
- Facilitating Complex Trait Analysis via Reduced Complexity Crosses.Trends in genetics : TIG · 2020Review
- Simultaneous SNP selection and adjustment for population structure in high dimensional prediction models.PLoS genetics · 2020Article
- Genome-Wide Association Study in Two Cohorts from a Multi-generational Mouse Advanced Intercross Line Highlights the Difficulty of Replication Due to Study-Specific Heterogeneity.G3 (Bethesda, Md.) · 2020Article
- Dating admixture events is unsolved problem in multi-way admixed populations.Briefings in bioinformatics · 2020Article
- Genome-wide Associations Reveal Human-Mouse Genetic Convergence and Modifiers of Myogenesis, CPNE1 and STC2.American journal of human genetics · 2019Article
- Genome-wide association study of inflorescence length of cultivated soybean based on the high-throughout single-nucleotide markers.Molecular genetics and genomics : MGG · 2019Article
- Using Heterogeneous Stocks for Fine-Mapping Genetically Complex Traits.Methods in molecular biology (Clifton, N.J.) · 2019Review
- Genome wide association analysis in a mouse advanced intercross line.Nature communications · 2018Article
- Replication and discovery of musculoskeletal QTLs in LG/J and SM/J advanced intercross lines.Physiological reports · 2018Article
- Genome-wide dissection of heterosis for yield traits in two-line hybrid rice populations.Scientific reports · 2017Article
- Variation in Leaf Respiration Rates at Night Correlates with Carbohydrate and Amino Acid Supply.Plant physiology · 2017Article
- Epistatic determinism of durum wheat resistance to the wheat spindle streak mosaic virus.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2017Article
- Identifying genes for neurobehavioural traits in rodents: progress and pitfalls.Disease models & mechanisms · 2017Review
- Fine-mapping of genes determining extrafusal fiber properties in murine soleus muscle.Physiological genomics · 2017Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Model organisms offer many advantages for the genetic analysis of complex traits. However, identification of specific genes is often hampered by a lack of recombination between the genomes of inbred progenitors. Recently, genome-wide association studies (GWAS) in humans have offered gene-level mapping resolution that is possible because of the large number of accumulated recombinations among unrelated human subjects. To obtain analogous improvements in mapping resolution in mice, we used a 34th generation advanced intercross line (AIL) derived from two inbred strains (SM/J and LG/J). We used simulations to show that familial relationships among subjects must be accounted for when analyzing these data; we then used a mixed model that included polygenic effects to address this problem in our own analysis. Using a combination of F(2) and AIL mice derived from the same inbred progenitors, we identified genome-wide significant, subcentimorgan loci that were associated with methamphetamine sensitivity, (e.g., chromosome 18; LOD = 10.5) and non-drug-induced locomotor activity (e.g., chromosome 8; LOD = 18.9). The 2-LOD support interval for the former locus contains no known genes while the latter contains only one gene (Csmd1). This approach is broadly applicable in terms of phenotypes and model organisms and allows GWAS to be performed in multigenerational crosses between and among inbred strains where familial relatedness is often unavoidable.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.