ArticleProceedings of the National Academy of Sciences of the United States of America2010
Actin-like cytoskeleton filaments contribute to cell mechanics in bacteria.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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Who cites it
72 citing papers in PubMed, 150 citations in OpenAlex.
- E. coli filament buckling modulates Min patterning and cell division.Nature communications · 2025Article
- Organic particle scavenging by marine bacteria: influences of bacterial nanoscale surface properties.Applied and environmental microbiology · 2025Article
- Transporter excess and clustering facilitate adaptor protein shuttling for bacterial efflux.Cell reports. Physical science · 2025Article
- Mechanics limits ecological diversity and promotes heterogeneity in confined bacterial communities.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- High Growth Rate of Diatoms Explained by Reduced Carbon Requirement and Low Energy Cost of Silica Deposition.Microbiology spectrum · 2023Article
- Bending stiffness ofLab on a chip · 2022Article
- Membrane rigidity regulates E. coli proliferation rates.Scientific reports · 2022Article
- The wall-less bacteriumiScience · 2021Article
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- Peptidoglycan: Structure, Synthesis, and Regulation.EcoSal Plus · 2021Article
- Understanding Beta-Lactam-Induced Lysis at the Single-Cell Level.Frontiers in microbiology · 2021Article
- How Can a Histidine Kinase Respond to Mechanical Stress?Frontiers in microbiology · 2021Article
- Morphology engineering: a new strategy to construct microbial cell factories.World journal of microbiology & biotechnology · 2020Review
- Cell biomechanics and mechanobiology in bacteria: Challenges and opportunities.APL bioengineering · 2020Review
- Critical Role for the Extended N Terminus of Chlamydial MreB in Directing Its Membrane Association and Potential Interaction with Divisome Proteins.Journal of bacteriology · 2020Article
- Correlative ex situ and Liquid-Cell TEM Observation of Bacterial Cell Membrane Damage Induced by Rough Surface Topology.International journal of nanomedicine · 2020Article
- Physical Constraints and Forces Involved in Phagocytosis.Frontiers in immunology · 2020Review
- The evolution of spherical cell shape; progress and perspective.Biochemical Society transactions · 2019Review
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12 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
A filamentous cytoskeleton largely governs the physical shape and mechanical properties of eukaryotic cells. In bacteria, proteins homologous to all three classes of eukaryotic cytoskeletal filaments have recently been discovered. These proteins are essential for the maintenance of bacterial cell shape and have been shown to guide the localization of key cell-wall-modifying enzymes. However, whether the bacterial cytoskeleton is stiff enough to affect the overall mechanical rigidity of a cell has not been probed. Here, we used an optical trap to measure the bending rigidity of live Escherichia coli cells. We find that the actin-homolog MreB contributes nearly as much to the stiffness of a cell as the peptidoglycan cell wall. By quantitatively modeling these measurements, our data indicate that the MreB is rigidly linked to the cell wall, increasing the mechanical stiffness of the overall system. These data are the first evidence that the bacterial cytoskeleton contributes to the mechanical integrity of a cell in much the same way as it does in eukaryotes.
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