ArticleProceedings of the National Academy of Sciences of the United States of America2010
Simulation of cell motility that reproduces the force-velocity relationship.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- 4polar3D single molecule imaging of 3D orientation in dense actin networks using ratiometric polarization splitting.Nature communications · 2026Article
- Nonlinear Stability in a Free Boundary Model of Active Locomotion.Archive for rational mechanics and analysis · 2026Article
- The mechanism of dynamic steady states in lamellipodia.PLoS computational biology · 2025Article
- Competing signaling pathways controls electrotaxis.iScience · 2025Article
- Liquid-like condensates mediate competition between actin branching and bundling.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Liquid-like condensates mediate competition between actin branching and bundling.bioRxiv : the preprint server for biology · 2023Article
- Article
- Mechanistic insights into actin force generation during vesicle formation from cryo-electron tomography.Developmental cell · 2022Article
- Discrete mechanical model of lamellipodial actin network implements molecular clutch mechanism and generates arcs and microspikes.PLoS computational biology · 2021Article
- The Actin Cytoskeleton as an Active Adaptive Material.Annual review of condensed matter physics · 2020Article
- A Tale of Two States: Normal and Transformed, With and Without Rigidity Sensing.Annual review of cell and developmental biology · 2019Review
- High Rac1 activity is functionally translated into cytosolic structures with unique nanoscale cytoskeletal architecture.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Building a dendritic actin filament network branch by branch: models of filament orientation pattern and force generation in lamellipodia.Biophysical reviews · 2018Review
- Structural organization and energy storage in crosslinked actin assemblies.PLoS computational biology · 2018Article
- Vinculin forms a directionally asymmetric catch bond with F-actin.Science (New York, N.Y.) · 2017Article
- Power transduction of actin filaments ratcheting in vitro against a load.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Control of actin-based motility through localized actin binding.Physical biology · 2013Article
- Branching and capping determine the force-velocity relationships of branching actin networks.Physical biology · 2013Article
- Distributed actin turnover in the lamellipodium and FRAP kinetics.Biophysical journal · 2013Article
- Migration of cells in a social context.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Many cells crawl by extending an actin-rich pseudopod. We have devised a simulation that describes how the polymerization kinetics of a branched actin filament network, coupled with excluded volume effects, powers the motility of crawling cells such as amoebae and fish keratocytes. Our stochastic simulation is based on the key fundamental properties of actin polymerization, namely growth, shrinkage, capping, branching, and nucleation, and also includes contributions from the creation and breaking of adhesive contacts with the substrate together with excluded volume effects related to filament packing. When reasonable values for appropriate constants were employed, this simulation generated a force-velocity relationship that resembled closely that observed experimentally. Our simulations indicated that excluded volume effects associated with actin filament branching lead to a decreased packing efficiency and resultant swelling of the cytoskeleton gel that contributes substantially to lamellipod protrusion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.