ArticleProceedings of the National Academy of Sciences of the United States of America2010
Crystal structure of a junction between two Z-DNA helices.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- Structural features of DNA and their potential contribution to blind mole rat (Nannospalax xanthodon) longevity.Biogerontology · 2025Article
- Zα and Zβ Localize ADAR1 to Flipons That Modulate Innate Immunity, Alternative Splicing, and Nonsynonymous RNA Editing.International journal of molecular sciences · 2025Review
- Structure-Function Analysis of RBP7910: An Editosome Z-Binding Protein in Trypanosomatids.Molecules (Basel, Switzerland) · 2023Article
- Structure and Formation of Z-DNA and Z-RNA.Molecules (Basel, Switzerland) · 2023Review
- Z-DNA and Z-RNA: Methods-Past and Future.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Novel eGZ-motif formed by regularly extruded guanine bases in a left-handed Z-DNA helix as a major motif behind CGG trinucleotide repeats.Nucleic acids research · 2022Article
- Nanomechanics of negatively supercoiled diaminopurine-substituted DNA.Nucleic acids research · 2021Article
- Removal of eDNA from fabrics using a novel laundry DNase revealed using high-resolution imaging.Scientific reports · 2021Article
- Dual conformational recognition by Z-DNA binding protein is important for the B-Z transition process.Nucleic acids research · 2020Article
- ALU non-B-DNA conformations, flipons, binary codes and evolution.Royal Society open science · 2020Review
- A-to-I editing of Malacoherpesviridae RNAs supports the antiviral role of ADAR1 in mollusks.BMC evolutionary biology · 2019Article
- Architectural Organization of Dinoflagellate Liquid Crystalline Chromosomes.Microorganisms · 2019Review
- Z-DNA and Z-RNA in human disease.Communications biology · 2019Review
- Sequence preference and structural heterogeneity of BZ junctions.Nucleic acids research · 2018Article
- The Cucurbit[7]Uril-Based Supramolecular Chemistry for Reversible B/Z-DNA Transition.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2018Article
- Translocation and deletion breakpoints in cancer genomes are associated with potential non-B DNA-forming sequences.Nucleic acids research · 2016Article
- Lanthanum induced B-to-Z transition in self-assembled Y-shaped branched DNA structure.Scientific reports · 2016Article
- Making the bend: DNA tertiary structure and protein-DNA interactions.International journal of molecular sciences · 2014Review
- Structural basis for Z-DNA binding and stabilization by the zebrafish Z-DNA dependent protein kinase PKZ.Nucleic acids research · 2013Article
- Reaction path ensemble of the B-Z-DNA transition: a comprehensive atomistic study.Nucleic acids research · 2013Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The double helix of DNA, when composed of dinucleotide purine-pyrimidine repeats, can adopt a left-handed helical structure called Z-DNA. For reasons not entirely understood, such dinucleotide repeats in genomic sequences have been associated with genomic instability leading to cancer. Adoption of the left-handed conformation results in the formation of conformational junctions: A B-to-Z junction is formed at the boundaries of the helix, whereas a Z-to-Z junction is commonly formed in sequences where the dinucleotide repeat is interrupted by single base insertions or deletions that bring neighboring helices out of phase. B-Z junctions are shown to result in exposed nucleotides vulnerable to chemical or enzymatic modification. Here we describe the three-dimensional structure of a Z-Z junction stabilized by Zalpha, the Z-DNA binding domain of the RNA editing enzyme ADAR1. We show that the junction structure consists of a single base pair and leads to partial or full disruption of the helical stacking. The junction region allows intercalating agents to insert themselves into the left-handed helix, which is otherwise resistant to intercalation. However, unlike a B-Z junction, in this structure the bases are not fully extruded, and the stacking between the two left-handed helices is not continuous.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.