ArticleProceedings of the National Academy of Sciences of the United States of America2010
Asymmetric phosphorylation through catalytic P(III) phosphoramidite transfer: enantioselective synthesis of D-myo-inositol-6-phosphate.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 77 citations in OpenAlex.
- Selective Phosphorylation of Phenols and Benzenediols by the Kinase PsiK and Variants Thereof.Angewandte Chemie (International ed. in English) · 2025Article
- Reviewing Glycosyl-Inositols: Natural Occurrence, Biological Roles, and Synthetic Techniques.Chembiochem : a European journal of chemical biology · 2025Review
- Cu-catalysed enantioselective radical heteroatomic S-O cross-coupling.Nature chemistry · 2023Article
- Mild and Chemoselective Phosphorylation of Alcohols Using a Ψ-Reagent.Organic letters · 2021Article
- Asymmetric Synthesis of Stereogenic Phosphorus P(V) Centers Using Chiral Nucleophilic Catalysis.Molecules (Basel, Switzerland) · 2021Article
- Catalytic asymmetric and stereodivergent oligonucleotide synthesis.Science (New York, N.Y.) · 2021Article
- Asymmetric Catalysis Mediated by Synthetic Peptides, Version 2.0: Expansion of Scope and Mechanisms.Chemical reviews · 2020Review
- Catalytic ChemoselectiveACS central science · 2020Article
- Regiodivergent Glycosylations of 6-Deoxy-erythronolide B and Oleandomycin-Derived Macrolactones Enabled by Chiral Acid Catalysis.Journal of the American Chemical Society · 2017Article
- Exploiting Enzymatic Dynamic Reductive Kinetic Resolution (DYRKR) in Stereocontrolled Synthesis.Advanced synthesis & catalysis · 2015Article
- Synthesis of densely phosphorylated bis-1,5-diphospho-myo-inositol tetrakisphosphate and its enantiomer by bidirectional P-anhydride formation.Angewandte Chemie (International ed. in English) · 2014Article
- Alternative synthetic tools to phospho-specific antibodies for phosphoproteome analysis: progress and prospects.Journal of chemical biology · 2013Review
- Electronic tuning of site-selectivity.Nature chemistry · 2012Article
- Site-selective bromination of vancomycin.Journal of the American Chemical Society · 2012Article
- An approach to the site-selective deoxygenation of hydroxy groups based on catalytic phosphoramidite transfer.Angewandte Chemie (International ed. in English) · 2012Article
- Combinatorial catalysis employing a visible enzymatic beacon in real time: synthetically versatile (pseudo)halometalation/carbocyclizations.Angewandte Chemie (International ed. in English) · 2011Article
- Scaffolding catalysts: highly enantioselective desymmetrization reactions.Angewandte Chemie (International ed. in English) · 2011Article
- Organocatalysis.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Despite the ubiquitous use of phosphoramidite chemistry in the synthesis of biophosphates, catalytic asymmetric phosphoramidite transfer remains largely unexplored for phosphate ester synthesis. We have discovered that a tetrazole-functionalized peptide, in the presence of 10-Å molecular sieves, functions as an enantioselective catalyst for phosphite transfer. This chemistry in turn has been used as the key step in a streamlined synthesis of myo-inositol-6-phosphate. Mechanistic insights implicate phosphate as a directing group for a highly selective kinetic resolution of a protected inositol monophosphate. This work represents a distinct and efficient method for the selective catalytic phosphorylation of natural products.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.