ArticleProceedings of the National Academy of Sciences of the United States of America2010
Ultraviolet A does not induce melanomas in a Xiphophorus hybrid fish model.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 77 citations in OpenAlex.
- UVA-induced DNA damage and mutations in human melanocytes: relevance for melanoma mutations.Nucleic acids research · 2025Article
- UVA Radiation, DNA Damage, and Melanoma.ACS omega · 2022Review
- Solar Ultraviolet Radiation Risk Estimates-A Comparison of Different Action Spectra and Detector Responsivities.International journal of environmental research and public health · 2021Article
- Mechanisms of UV-induced mutations and skin cancer.Genome instability & disease · 2020Article
- Intra-Strain Genetic Variation of Platyfish (Frontiers in genetics · 2020Article
- Enhanced ambient UVB radiation affects post-mating, but not pre-mating sexual traits in a fish.Oecologia · 2019Article
- Roles of UVA radiation and DNA damage responses in melanoma pathogenesis.Environmental and molecular mutagenesis · 2018Review
- Exposure to fluorescent light triggers down regulation of genes involved with mitotic progression in Xiphophorus skin.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2015Article
- Molecular genetic response of Xiphophorus maculatus-X. couchianus interspecies hybrid skin to UVB exposure.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2015Article
- UVB-induced gene expression in the skin of Xiphophorus maculatus Jp 163 B.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2014Article
- Characterization and differential expression of CPD and 6-4 DNA photolyases in Xiphophorus species and interspecies hybrids.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2014Article
- Cortisol release in response to UVB exposure in Xiphophorus fish.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2014Article
- Acute exposure to ultraviolet-B radiation modulates sex steroid hormones and receptor expression in the skin and may contribute to the sex bias of melanoma in a fish model.Pigment cell & melanoma research · 2014Article
- Targeting nitric oxide signaling with nNOS inhibitors as a novel strategy for the therapy and prevention of human melanoma.Antioxidants & redox signaling · 2013Article
- Impact of silicon-based quantum dots on the antioxidative system in white muscle of Carassius auratus gibelio.Fish physiology and biochemistry · 2012Article
- Melanoma induction by ultraviolet A but not ultraviolet B radiation requires melanin pigment.Nature communications · 2012Article
- Recent advances in sunlight-induced carcinogenesis using the Xiphophorus melanoma model.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2012Article
- UV wavelength-dependent DNA damage and human non-melanoma and melanoma skin cancer.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2012Review
- New agents for prevention of ultraviolet-induced nonmelanoma skin cancer.Seminars in cutaneous medicine and surgery · 2011Article
- The deceptive nature of UVA tanning versus the modest protective effects of UVB tanning on human skin.Pigment cell & melanoma research · 2011Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
We examined the wavelength dependence of ultraviolet (UV) ra-diation (UVR)-induced melanoma in a Xiphophorus backcross hybrid model previously reported to be susceptible to melanoma induction by ultraviolet A (UVA) and visible light. Whereas ultraviolet B (UVB) irradiation of neonates yielded high frequencies of melanomas in pigmented fish, UVA irradiation resulted in melanoma frequencies that were not significantly different from unirradiated fish. Spontaneous and UV-induced melanoma frequencies correlated with the degree of pigmentation as expected from previous studies, and the histopathology phenotypes of the melanomas were not found in significantly different proportions in UV-treated and -untreated tumor-bearing fish. Our results support the conclusion that a brief early-life exposure to UVB radiation causes melanoma formation in this animal model. These data are consistent with an essential role for direct DNA damage, including cyclobutane dimers and (6-4) photoproducts, in the etiology of melanoma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.