ArticleProceedings of the National Academy of Sciences of the United States of America2010
Unique characteristics of Ca2+ homeostasis of the trans-Golgi compartment.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed.
- AMH regulates ovary size by counteracting the positive influence of clustered ovarian follicle growth.Human reproduction (Oxford, England) · 2026Article
- The beta1-adrenergic receptor in the heart.Cell death discovery · 2025Review
- Transcriptomic profiles of susceptibility and resilience to stress in the amygdala and hippocampus of male rats.Neurobiology of stress · 2025Article
- Review
- Chemigenetic Ca2+ indicators report elevated Ca2+ levels in endothelial Weibel-Palade bodies.PloS one · 2025Article
- CaBiophysics reports · 2024Article
- Acute GARP depletion disrupts vesicle transport, leading to severe defects in sorting, secretion, and O-glycosylation.bioRxiv : the preprint server for biology · 2024Article
- Article
- The ion channels of endomembranes.Physiological reviews · 2024Review
- Calcium flow at ER-TGN contact sites facilitates secretory cargo export.Molecular biology of the cell · 2024Article
- The organization and function of the Golgi apparatus in dendrite development and neurological disorders.Genes & diseases · 2023Review
- Ratiometric measurement of MAM CaNature communications · 2023Article
- Neuroimmunomodulatory properties of polysialic acid.Glycoconjugate journal · 2023Review
- The ins and outs of mammary gland calcium and zinc transport: A brief review.JDS communications · 2023Review
- Mendelian Disorders in an Interstitial Cystitis/Bladder Pain Syndrome Cohort.Advanced genetics (Hoboken, N.J.) · 2023Article
- The evolution of organellar calcium mapping technologies.Cell calcium · 2022Review
- Golgi Complex: A Signaling Hub in Cancer.Cells · 2022Review
- Review
- GARP dysfunction results in COPI displacement, depletion of Golgi v-SNAREs and calcium homeostasis proteins.Frontiers in cell and developmental biology · 2022Article
- CaFaculty reviews · 2022Review
5 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Taking advantage of a fluorescent Ca(2+) indicator selectively targeted to the trans-Golgi lumen, we here demonstrate that its Ca(2+) homeostatic mechanisms are distinct from those of the other Golgi subcompartments: (i) Ca(2+) uptake depends exclusively on the activity of the secretory pathway Ca(2+) ATPase1 (SPCA1), whereas the sarco-endoplasmic reticulum Ca(2+) ATPase (SERCA) is excluded; (ii) IP(3) generated by receptor stimulation causes Ca(2+) uptake rather than release; (iii) Ca(2+) release can be triggered by activation of ryanodine receptors in cells endowed with robust expression of the latter channels (e.g., in neonatal cardiac myocyte). Finally, we show that, knocking down the SPCA1, and thus altering the trans-Golgi Ca(2+) content, specific functions associated with this subcompartment, such as sorting of proteins to the plasma membrane through the secretory pathway, and the structure of the entire Golgi apparatus are dramatically altered.
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