ArticleProceedings of the National Academy of Sciences of the United States of America2010
Gamma(c) deficiency precludes CD8+ T cell memory despite formation of potent T cell effectors.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- The POSH scaffold protein is essential for signal coordination leading to CD8 T cell differentiation and survival.Frontiers in immunology · 2025Article
- Optimising IL-2 for Cancer Immunotherapy.Immune network · 2024Review
- Exhaustion‑like dysfunction of T and NKT cells in an X‑linked severe combined immunodeficiency patient with maternal engraftment by single‑cell analysis.International journal of molecular medicine · 2023Article
- Review
- Allospecific Memory B Cell Responses Are Dependent on Autophagy.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2018Article
- Identification of lineage-specifying cytokines that signal all CD8Nature immunology · 2017Article
- The MicroRNA miR-191 Supports T Cell Survival Following Common γ Chain Signaling.The Journal of biological chemistry · 2016Article
- IL2Rβ-dependent signals drive terminal exhaustion and suppress memory development during chronic viral infection.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- microRNAs function in CD8+T cell biology.Journal of leukocyte biology · 2015Review
- A cytokine cocktail directly modulates the phenotype of DC-enriched anti-tumor T cells to convey potent anti-tumor activities in a murine model.Cancer immunology, immunotherapy : CII · 2013Article
- The survival of memory CD8 T cells that is mediated by IL-15 correlates with sustained protection against malaria.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- MicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancer.Immunity · 2013Article
- Modulating the differentiation status of ex vivo-cultured anti-tumor T cells using cytokine cocktails.Cancer immunology, immunotherapy : CII · 2013Article
- Conditional deletion of cytokine receptor chains reveals that IL-7 and IL-15 specify CD8 cytotoxic lineage fate in the thymus.The Journal of experimental medicine · 2012Article
- Homeostatic maintenance of T cells and natural killer cells.Cellular and molecular life sciences : CMLS · 2012Review
- Article
- Memory CD8 T cells specific for plasmodia liver-stage antigens maintain protracted protection against malaria.Frontiers in immunology · 2012Article
- Interleukin-2 rescues helpless effector CD8+ T cells by diminishing the susceptibility to TRAIL mediated death.Immunology letters · 2011Article
- CD8(+) T cells: foot soldiers of the immune system.Immunity · 2011Review
- Cytokines and the inception of CD8 T cell responses.Trends in immunology · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several cytokines (including IL-2, IL-7, IL-15, and IL-21) that signal through receptors sharing the common gamma chain (gamma(c)) are critical for the generation and peripheral homeostasis of naive and memory T cells. Recently, we demonstrated that effector functions fail to develop in CD4(+) T cells that differentiate in the absence of gamma(c). To assess the role of gamma(c) cytokines in cell-fate decisions that condition effector versus memory CD8(+) T cell generation, we compared the response of CD8(+) T cells from gamma(c)(+) or gamma(c)(-) P14 TCR transgenic mice after challenge with lymphocytic choriomeningitis virus. The intrinsic IL-7-dependent survival defect of gamma(c)(-) naive CD8(+) T cells was corrected by transgenic expression of human Bcl-2. We demonstrated that although gamma(c)-dependent signals are dispensable for the initial expansion and the acquisition of cytotoxic functions following antigenic stimulation, they condition the terminal proliferation and differentiation of CD8(+) effector T cells (i.e., KLRG1(high) CD127(low) short-lived effector T cells) via the transcription factor, T-bet. Moreover, the gamma(c)-dependent signals that are critical for memory T cell formation are not rescued by Bcl2 overexpression. Together, these data reveal an unexpected divergence in the requirement for gamma(c) cytokines in the differentiation of CD4(+) versus CD8(+) cytotoxic T lymphocytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.