ArticleProceedings of the National Academy of Sciences of the United States of America2010
A defective Il15 allele underlies the deficiency in natural killer cell activity in nonobese diabetic mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- Regulation of Diabetogenic Immunity by IL-15-Activated Regulatory CD8 T Cells in Type 1 Diabetes.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Preproinsulin Designer Antigens Excluded from Endoplasmic Reticulum Suppressed Diabetes Development in NOD Mice by DNA Vaccination.Molecular therapy. Methods & clinical development · 2019Article
- Outbreak of Opportunistic Ascending Pyelonephritis with Numerous Yeast after Experimental Humanization Surgery in NOD.Cg-Comparative medicine · 2018Article
- The Four-Way Stop Sign: Viruses, 12-Lipoxygenase, Islets, and Natural Killer Cells in Type 1 Diabetes Progression.Frontiers in endocrinology · 2017Article
- Influenza H3N2 infection of the collaborative cross founder strains reveals highly divergent host responses and identifies a unique phenotype in CAST/EiJ mice.BMC genomics · 2016Article
- Intestinal microbiota modulates gluten-induced immunopathology in humanized mice.The American journal of pathology · 2015Article
- Intraluminal administration of poly I:C causes an enteropathy that is exacerbated by administration of oral dietary antigen.PloS one · 2014Article
- Interleukin-15 plays an essential role in the pathogenesis of autoimmune diabetes in the NOD mouse.Diabetologia · 2012Article
- Current advances in humanized mouse models.Cellular & molecular immunology · 2012Review
- Genetic dissection of NK cell responses.Frontiers in immunology · 2012Article
- What we are learning on HTLV-1 pathogenesis from animal models.Frontiers in microbiology · 2012Article
- Article
- Cardiovascular adaptations of pregnancy in T and B cell-deficient mice.Biology of reproduction · 2011Article
- The utility of the new generation of humanized mice to study HIV-1 infection: transmission, prevention, pathogenesis, and treatment.Retrovirology · 2011Review
- Interferon gamma contributes to preimplantation embryonic development and to implantation site structure in NOD mice.Human reproduction (Oxford, England) · 2010Article
- Natural killer cells in NOD.NK1.1 mice acquire cytolytic function during viral infection and provide protection against cytomegalovirus.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The nonobese diabetic (NOD) mouse strain has a genetic deficiency in natural killer (NK) cells. This defect underlies this strain's utility in several experimental settings; in particular, it promotes engraftment of human tissue in NOD hosts during the generation of "humanized" mouse models. We have mapped the major NK-cell defect in the NOD vs. C57BL/6 (B6) strain to an inadequately expressed Il15 allele. Treatment of NOD mice with a reagent that specifically enhances interleukin (IL)-15 bioavailability normalized NK-cell numbers and activity in the absence of nonspecific stimulation. These findings raise the possibility of exploiting reagents that impact the IL-15 receptor pathway to facilitate construction of humanized mouse models on non-NOD genetic backgrounds.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.