ArticleCerebral cortex (New York, N.Y. : 1991)2011
Lrp12/Mig13a reveals changing patterns of preplate neuronal polarity during corticogenesis that are absent in reeler mutant mice.
Article in Cerebral cortex (New York, N.Y. : 1991), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
- LRP12 promotes gastric cancer progression through AKT/mTOR signaling and M2 macrophage-mediated immunosuppression.Scientific reports · 2025Article
- Comprehensive characterization of migration profiles of murine cerebral cortical neurons during development using FlashTag labeling.iScience · 2021Article
- Spatial confinement of receptor activity by tyrosine phosphatase during directional cell migration.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Loss of Dmrt5 Affects the Formation of the Subplate and Early Corticogenesis.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Development of piriform cortex interhemispheric connections via the anterior commissure: progressive and regressive strategies.Brain structure & function · 2018Article
- Article
- Functional Roles of the Interaction of APP and Lipoprotein Receptors.Frontiers in molecular neuroscience · 2017Review
- Reelin Prevents Apical Neurite Retraction during Terminal Translocation and Dendrite Initiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Extracortical origin of some murine subplate cell populations.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Analysis of preplate splitting and early cortical development illuminates the biology of neurological disease.Frontiers in pediatrics · 2014Review
- Molecules and mechanisms that regulate multipolar migration in the intermediate zone.Frontiers in cellular neuroscience · 2014Review
- Transmembrane protein MIG-13 links the Wnt signaling and Hox genes to the cell polarity in neuronal migration.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- GPR56 and the developing cerebral cortex: cells, matrix, and neuronal migration.Molecular neurobiology · 2013Review
- WNT3 inhibits cerebellar granule neuron progenitor proliferation and medulloblastoma formation via MAPK activation.PloS one · 2013Article
- The role of Rho GTPase proteins in CNS neuronal migration.Developmental neurobiology · 2011Review
- Migration, early axonogenesis, and Reelin-dependent layer-forming behavior of early/posterior-born Purkinje cells in the developing mouse lateral cerebellum.Neural development · 2010Article
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Abstract
During corticogenesis, the earliest generated neurons form the preplate, which evolves into the marginal zone and subplate. Lrp12/Mig13a, a mammalian gene related to the Caenorhabditis elegans neuroblast migration gene mig-13, is expressed in a subpopulation of preplate neurons that undergo ventrally directed tangential migrations in the preplate layer and pioneer axon projections to the anterior commissure. As the preplate separates, Lrp12/Mig13a-positive neurons polarize in the radial plane and form a pseudocolumnar pattern, prior to moving to a deeper position within the emerging subplate layer. These changes in neuronal polarity do not occur in reeler mutant mice, revealing the earliest known defect in reeler cortical patterning and suggesting that the alignment of preplate neurons into a pseudolayer facilitates the movement of later-born radially migrating neurons into the emerging cortical plate.
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