ReviewCurrent opinion in pharmacology2010
Osmolytes and ion transport modulators: new strategies for airway surface rehydration.
Review in Current opinion in pharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 30 citations in OpenAlex.
- Effect of inhaled dust mite allergen on regional particle deposition and mucociliary clearance in allergic asthmatics.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2011Trial
- Vascular mechanotransduction.Physiological reviews · 2023Review
- Article
- Hypertonic saline is effective in the prevention and treatment of mucus obstruction, but not airway inflammation, in mice with chronic obstructive lung disease.American journal of respiratory cell and molecular biology · 2013Article
- Targeting a genetic defect: cystic fibrosis transmembrane conductance regulator modulators in cystic fibrosis.European respiratory review : an official journal of the European Respiratory Society · 2013Review
- Regulation of ENaC biogenesis by the stress response protein SERP1.Pflugers Archiv : European journal of physiology · 2012Article
- Future directions in early cystic fibrosis lung disease research: an NHLBI workshop report.American journal of respiratory and critical care medicine · 2012Article
- Molecular profiling of the human nasal epithelium: A proteomics approach.Journal of proteomics · 2011Article
- Measurement of the airway surface liquid volume with simple light refraction microscopy.American journal of respiratory cell and molecular biology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Mucociliary clearance (MCC) in CF lung disease is limited by airway dehydration, leading to persistent bacterial infection and inflammation in the airways. Agents designed to rehydrate the airway mucosa lead to improved MCC. Hyperosmolar agents, such as hypertonic saline and mannitol, create a luminal osmotic gradient, drawing water into the dehydrated ASL. Ion transport modulators function to activate alternative chloride channels and/or to block sodium hyperabsorption that occurs through a dysregulated ENaC channel. Combinations of these therapies may result in a synergistic improvement in airway hydration, and thus, restore MCC. Active ongoing phase II and III trials of new pharmacotherapeutics are covered in this review.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.