ReviewAgeing research reviews2010
Models of accelerated sarcopenia: critical pieces for solving the puzzle of age-related muscle atrophy.
Review in Ageing research reviews, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 149 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
149 citing papers in PubMed, 4 syntheses or guidelines pooled it, 298 citations in OpenAlex.
- Association of muscle wasting with mortality risk among adults: A systematic review and meta-analysis of prospective studies.Journal of cachexia, sarcopenia and muscle · 2023Pooled it
- The Association Between Diabetes Mellitus and Risk of Sarcopenia: Accumulated Evidences From Observational Studies.Frontiers in endocrinology · 2021Pooled it
- Association between Sarcopenia and Metabolic Syndrome in Middle-Aged and Older Non-Obese Adults: A Systematic Review and Meta-Analysis.Nutrients · 2018Pooled it
- Relationship between sarcopenia and physical activity in older people: a systematic review and meta-analysis.Clinical interventions in aging · 2017Pooled it
- Effect of personalized dietary advice to increase protein intake on food consumption and the environmental impact of the diet in community-dwelling older adults: results from the PROMISS trial.European journal of nutrition · 2022Trial
- Randomised Controlled Trial of Fish Oil Supplementation on Responsiveness to Resistance Exercise Training in Sarcopenic Older Women.Nutrients · 2022Trial
- Time-restricted eating and concurrent exercise training reduces fat mass and increases lean mass in overweight and obese adults.Physiological reports · 2021Trial
- Circulating Mediators of Apoptosis and Inflammation in Aging; Physical Exercise Intervention.International journal of environmental research and public health · 2021Trial
- Effect of Creatine Supplementation Dosing Strategies on Aging Muscle Performance.The journal of nutrition, health & aging · 2019Trial
- Abdominal lean muscle is associated with lower mortality among kidney waitlist candidates.Clinical transplantation · 2017Trial
- Prevalence and definition of sarcopenia in community dwelling older people. Data from the Berlin aging study II (BASE-II).Zeitschrift fur Gerontologie und Geriatrie · 2016Trial
- Creatine supplementation post-exercise does not enhance training-induced adaptations in middle to older aged males.European journal of applied physiology · 2014Trial
- Sarcopenia during androgen-deprivation therapy for prostate cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2012Trial
- Posttraumatic Stress Disorder and Handgrip Strength Among World Trade Center Firefighters and Emergency Medical Responders.International journal of environmental research and public health · 2026Article
- Accelerated biological aging and risk of sarcopenia: evidence from 29,000 Chinese adults.Biology of sport · 2026Article
- Associations between physical activity, socioeconomic and sociodemographic factors, and risk of sarcopenia in older adults in Northeast Brazil.BMC public health · 2025Article
- What Is 'Muscle Health'? A Narrative Review and Conceptual Framework.Journal of functional morphology and kinesiology · 2025Review
- Frailty Assessment in an Aging Mouse Model.Journal of visualized experiments : JoVE · 2025Article
- The association of calf circumference with nutritional risk and mortality in type 2 diabetes aged over 80 years inpatient Chinese.Diabetology & metabolic syndrome · 2025Article
- Analysis of Intrinsic Capacity and Associated Factors of the Older Adults in Kunshan Community.Psychiatry and clinical psychopharmacology · 2025Article
89 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Sarcopenia, the age-related loss of skeletal muscle mass, is a significant public health concern that continues to grow in relevance as the population ages. Certain conditions have the strong potential to coincide with sarcopenia to accelerate the progression of muscle atrophy in older adults. Among these conditions are co-morbid diseases common to older individuals such as cancer, kidney disease, diabetes, and peripheral artery disease. Furthermore, behaviors such as poor nutrition and physical inactivity are well-known to contribute to sarcopenia development. However, we argue that these behaviors are not inherent to the development of sarcopenia but rather accelerate its progression. In the present review, we discuss how these factors affect systemic and cellular mechanisms that contribute to skeletal muscle atrophy. In addition, we describe gaps in the literature concerning the role of these factors in accelerating sarcopenia progression. Elucidating biochemical pathways related to accelerated muscle atrophy may allow for improved discovery of therapeutic treatments related to sarcopenia.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.