ArticleFungal genetics and biology : FG & B2010
Analysis of a novel calcium auxotrophy in Aspergillus nidulans.
Article in Fungal genetics and biology : FG & B, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Transcription factors SltA and CrzA reversely regulate calcium homeostasis under calcium-limited conditions.Applied and environmental microbiology · 2023Article
- The CAntimicrobial agents and chemotherapy · 2021Article
- Precise Expression ofmSphere · 2020Article
- Tolerance to alkaline ambient pH in Aspergillus nidulans depends on the activity of ENA proteins.Scientific reports · 2020Article
- Defining the transcriptional responses ofMicrobial genomics · 2020Article
- Mutual independence of alkaline- and calcium-mediated signalling in Aspergillus fumigatus refutes the existence of a conserved druggable signalling nexus.Molecular microbiology · 2017Article
- Article
- Proteolytic activation of both components of the cation stress-responsive Slt pathway in Aspergillus nidulans.Molecular biology of the cell · 2016Article
- Palmitoylation of the Cysteine Residue in the DHHC Motif of a Palmitoyl Transferase Mediates Ca2+ Homeostasis in Aspergillus.PLoS genetics · 2016Article
- Article
- A second component of the SltA-dependent cation tolerance pathway in Aspergillus nidulans.Fungal genetics and biology : FG & B · 2015Article
- Deletion of PdMit1, a homolog of yeast Csg1, affects growth and Ca(2+) sensitivity of the fungus Penicillium digitatum, but does not alter virulence.Research in microbiology · 2015Article
- The observation of plcA mutation and localization in Aspergillus nidulans.Journal of microbiology (Seoul, Korea) · 2014Article
- Article
- Functional analysis of the Aspergillus nidulans kinome.PloS one · 2013Article
- The pmr gene, encoding a Ca2+-ATPase, is required for calcium and manganese homeostasis and normal development of hyphae and conidia in Neurospora crassa.Eukaryotic cell · 2012Article
- Endosomal maturation by Rab conversion in Aspergillus nidulans is coupled to dynein-mediated basipetal movement.Molecular biology of the cell · 2012Article
- Functional characterization of an Aspergillus fumigatus calcium transporter (PmcA) that is essential for fungal infection.PloS one · 2012Article
- Searching for gold beyond mitosis: Mining intracellular membrane traffic in Aspergillus nidulans.Cellular logistics · 2012Article
- Rescue of Aspergillus nidulans severely debilitating null mutations in ESCRT-0, I, II and III genes by inactivation of a salt-tolerance pathway allows examination of ESCRT gene roles in pH signalling.Journal of cell science · 2011Article
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
In Aspergillus nidulans a combination of null mutations in halA, encoding a protein kinase, and sltA, encoding a zinc-finger transcription factor having no yeast homologues, results in an elevated calcium requirement ('calcium auxotrophy') without impairing net calcium uptake. sltA(-) (+/-halA(-)) mutations result in hypertrophy of the vacuolar system. In halA(-)sltA(-) (and sltA(-)) strains, transcript levels for pmcA and pmcB, encoding vacuolar Ca(2+)-ATPase homologues, are highly elevated, suggesting a regulatory relationship between vacuolar membrane area and certain vacuolar membrane ATPase levels. Deletion of both pmcA and pmcB strongly suppresses the 'calcium auxotrophy'. Therefore the 'calcium auxotrophy' possibly results from excessive vacuolar calcium sequestration, causing cytosolic calcium deprivation. Null mutations in nhaA, homologous to Saccharomyces cerevisiae NHA1, encoding a plasma membrane Na(+)/H(+) antiporter effluxing Na(+) and K(+), and a non-null mutation in trkB, homologous to S. cerevisiae TRK1, encoding a plasma membrane high affinity K(+) transporter, also suppress the calcium auxotrophy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.