ReviewAdvanced drug delivery reviews2010
Chronopharmaceutical drug delivery systems: Hurdles, hype or hope?
Review in Advanced drug delivery reviews, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 72 citations in OpenAlex.
- Impact of time-of-day on immunochemotherapy efficacy in non-small cell lung cancer.Annals of medicine and surgery (2012) · 2026Article
- Delivery Strategies and Clinical Significance of Oral Colon-targeted Drug Delivery Systems.AAPS PharmSciTech · 2026Review
- Nanomaterial-enabled drug delivery systems for circadian medicine: bridging direct rhythm modulation and chronotherapy.RSC advances · 2025Review
- Chrono-tailored drug delivery systems: recent advances and future directions.Drug delivery and translational research · 2024Review
- Orthogonal Gelations to Synthesize Core-Shell Hydrogels Loaded with Nanoemulsion-Templated Drug Nanoparticles for Versatile Oral Drug Delivery.Advanced healthcare materials · 2023Article
- Compression-coated pulsatile chronomodulated therapeutic system: QbD assisted optimization.Drug delivery · 2022Article
- Development of Nanocrystal Compressed Minitablets for Chronotherapeutic Drug Delivery.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Circadian rhythms and cancers: the intrinsic links and therapeutic potentials.Journal of hematology & oncology · 2022Review
- Exploring the link between chronobiology and drug delivery: effects on cancer therapy.Journal of molecular medicine (Berlin, Germany) · 2021Review
- Application of coating technology to chronotherapeutic drug delivery systems: Recent publications and patents.Current research in pharmacology and drug discovery · 2021Review
- Breakthroughs in modern cancer therapy and elusive cardiotoxicity: Critical research-practice gaps, challenges, and insights.Medicinal research reviews · 2018Review
- Molecular Aspects of Circadian Pharmacology and Relevance for Cancer Chronotherapy.International journal of molecular sciences · 2017Review
- Light in diagnosis, therapy and surgery.Nature biomedical engineering · 2017Article
- Marketed New Drug Delivery Systems for Opioid Agonists/Antagonists Administration: A Rapid Overview.Addiction & health · 2016Review
- Leveraging electrokinetics for the active control of dendritic fullerene-1 release across a nanochannel membrane.Nanoscale · 2015Article
- Impedance characterization, degradation, and in vitro biocompatibility for platinum electrodes on BioMEMS.Biomedical microdevices · 2015Article
- Photoexpulsion of surface-grafted ruthenium complexes and subsequent release of cytotoxic cargos to cancer cells from mesoporous silica nanoparticles.Journal of the American Chemical Society · 2013Article
- Circadian models of serum potassium, sodium, and calcium concentrations in healthy individuals and their application to cardiac electrophysiology simulations at individual level.Computational and mathematical methods in medicine · 2013Article
- Photoswitchable nanoparticles for triggered tissue penetration and drug delivery.Journal of the American Chemical Society · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The current advances in chronobiology and the knowledge gained from chronotherapy of selected diseases strongly suggest that "the one size fits all at all times" approach to drug delivery is no longer substantiated, at least for selected bioactive agents and disease therapy or prevention. Thus, there is a critical and urgent need for chronopharmaceutical research (e.g., design and evaluation of robust, spatially and temporally controlled drug delivery systems that would be clinically intended for chronotherapy by different routes of administration). This review provides a brief overview of current drug delivery system intended for chronotherapy. In theory, such an ideal "magic pill" preferably with affordable cost, would improve the safety, efficacy and patient compliance of old and new drugs. However, currently, there are three major hurdles for the successful transition of such system from laboratory to patient bedside. These include the challenges to identify adequate (i) rhythmic biomaterials and systems, (ii) rhythm engineering and modeling, perhaps using system biology and (iii) regulatory guidance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.