Trial reportAIDS patient care and STDs2010
Disparities in outcomes for African American and Latino subjects in the Flexible Initial Retrovirus Suppressive Therapies (FIRST) trial.
Trial report in AIDS patient care and STDs, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03331978 (A Randomized Controlled Trial of an Antiretroviral Treatment Adherence Intervention for HIV+ African Americans), which is not on this map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Controlled Trial of an Antiretroviral Treatment Adherence Intervention for HIV+ African Americans
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of HIV/AIDS survival and delayed diagnosis among Hispanics in the United States.Journal of immigrant and minority health · 2012Pooled it
- HealthCall delivered via smartphone to reduce co-occurring drug and alcohol use in HIV-infected adults: A randomized pilot trial.Journal of substance abuse treatment · 2017Trial
- Factors associated with adherence amongst 5295 people receiving antiretroviral therapy as part of an international trial.The Journal of infectious diseases · 2013Trial
- Time Spent with HIV Viral Load > 1500 Copies/mL Among Persons Engaged in Continuity HIV Care in an Urban Clinic in the United States, 2010-2015.AIDS and behavior · 2018Article
- MSM in Bogotá are living with HIV for extended periods without diagnosis or treatment.International journal of STD & AIDS · 2017Article
- Antiretroviral Therapy: Racial Disparities among Publicly Insured Californians with HIV.Journal of health care for the poor and underserved · 2017Article
- Disparities in achieving and sustaining viral suppression among a large cohort of HIV-infected persons in care - Washington, DC.AIDS care · 2016Article
- Shifting the HIV Training and Research Paradigm to Address Disparities in HIV Outcomes.AIDS and behavior · 2016Article
- The Contribution of Missed Clinic Visits to Disparities in HIV Viral Load Outcomes.American journal of public health · 2015Article
- The Effect of Structural Violence on Patients with Sickle Cell Disease.Journal of health care for the poor and underserved · 2015Article
- Neurocognitive change in the era of HIV combination antiretroviral therapy: the longitudinal CHARTER study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2015Article
- Racial/ethnic differences in trust in health care: HIV conspiracy beliefs and vaccine research participation.Journal of general internal medicine · 2014Article
- Association of self-reported race with AIDS death in continuous HAART users in a cohort of HIV-infected women in the United States.AIDS (London, England) · 2013Article
- The Hispanic HIV Epidemic.Current infectious disease reports · 2013Article
- Examining the link between patient satisfaction and adherence to HIV care: a structural equation model.PloS one · 2013Article
- Article
- Differential predictors of medication adherence in HIV: findings from a sample of African American and Caucasian HIV-positive drug-using adults.AIDS patient care and STDs · 2012Article
- Risk factors for missed HIV primary care visits among men who have sex with men.Journal of behavioral medicine · 2012Article
- Operationalizing treatment as prevention in Los Angeles County: antiretroviral therapy use and factors associated with unsuppressed viral load in the Ryan White system of care.AIDS patient care and STDs · 2012Article
- A binational study of patient-initiated changes to antiretroviral therapy regimen among HIV-positive Latinos living in the Mexico-U.S. border region.AIDS and behavior · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
To benefit maximally from antiretroviral therapy, patients with HIV infection must enter care before their disease is advanced and adhere to care. We sought to determine if and where on this continuum of care racial/ethnic disparities were evident. Data from the Flexible Initial Retrovirus Suppressive Therapies (FIRST) trial, which evaluated three strategies for initial HIV therapy, were compared for White, African American, and Latino subjects. Outcomes included progression of disease and death, HIV viral suppression, and change in CD4(+) cell count. Multivariate Cox proportional hazard models adjusted for known predictors of survival. There were 1357 subjects, including 368 non-Latino white, 751 non-Latino African American, and 238 Latino subjects. At baseline, the two latter groups were more likely to have had AIDS and had lower CD4(+) cell counts than white subjects. In follow-up, African American subjects had lower self-reported adherence to therapy, lower CD4(+) cell count increases, and lower odds of viral suppression. African American and Latino subjects had unadjusted hazard ratios of progression of disease or death of 1.57 (1.17, 2.10; p = 0.0025) and 1.57 (1.09, 2.26; p = 0.02), respectively. Adjusting for baseline differences and differences in adherence, CD4(+) cell count change, and viral suppression accounted for the disparities in outcomes. Opportunities to reduce disparities in outcomes for African American and Latino patients exist along the continuum of HIV care. Efforts to promote access to HIV testing and care and to improve adherence have the potential to reduce racial/ethnic disparities in outcomes of patients with HIV infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.