Endogenous neurosteroid synthesis modulates seizure frequency.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

32 citing papers in PubMed, 62 citations in OpenAlex.

1. Progesterone vs placebo therapy for women with epilepsy: A randomized clinical trial.Neurology · 2012
   Trial
2. Spontaneous Seizure Outcomes in Mice Using an Improved Version of the Pilocarpine Model of Temporal Lobe Epilepsy.International journal of molecular sciences · 2025
   Article
3. Association between retinal thickness and disease characteristics in adult epilepsy: A cross-sectional OCT evaluation.Epilepsia open · 2024
   Article
4. Sex and gonadectomy modify behavioral seizure susceptibility and mortality in a repeated low-dose kainic acid systemic injection paradigm in mice.Epilepsia open · 2023
   Article
5. Sex and gonadectomy modify behavioral seizure susceptibility and mortality in a repeated low-dose kainic acid systemic injection paradigm in mice.bioRxiv : the preprint server for biology · 2023
   Article
6. Seizure-induced overexpression of NPY induces epileptic tolerance in a mouse model of spontaneous recurrent seizures.Frontiers in molecular neuroscience · 2022
   Article
7. Limbic progesterone receptor activity enhances neuronal excitability and seizures.Epilepsia · 2021
   Article
8. Progesterone modulates neuronal excitability bidirectionally.Neuroscience letters · 2021
   Review
9. Reduced neurosteroid potentiation of GABAAnnals of clinical and translational neurology · 2020
   Article
10. Progesterone receptor activation regulates seizure susceptibility.Annals of clinical and translational neurology · 2019
    Article
11. Neurosteroid regulation of GABABrain research · 2019
    Review
12. A novel therapeutic approach for treatment of catamenial epilepsy.Neurobiology of disease · 2018
    Article
13. Catamenial-like seizure exacerbation in mice with targeted ablation of extrasynaptic δGABA-a receptors in the brain.Journal of neuroscience research · 2017
    Article
14. Neurosteroid-sensitive δ-GABAEpilepsia · 2017
    Article
15. Neurosteroids and their role in sex-specific epilepsies.Neurobiology of disease · 2014
    Review
16. Neurosteroid interactions with synaptic and extrasynaptic GABA(A) receptors: regulation of subunit plasticity, phasic and tonic inhibition, and neuronal network excitability.Psychopharmacology · 2013
    Review
17. GABAergic transmission in temporal lobe epilepsy: the role of neurosteroids.Experimental neurology · 2013
    Review
18. Temporal lobe epilepsy exacerbation during pharmacological inhibition of endogenous neurosteroid synthesis.BMJ case reports · 2013
    Article
19. Neuroendocrine aspects of catamenial epilepsy.Hormones and behavior · 2013
    Review
20. Neurosteroids and GABAergic signaling in health and disease.Biomolecular concepts · 2013
    Review

Corrections and comments

• Commented on by
  Does exercise correct dysregulation of neurosteroid levels induced by epilepsy?2010

Authors and funding

5 authors at 1 institution in 1 country.

Funding

Abstract

Indexed as