Trial reportAnnals of neurology2010
Crossover trial of gabapentin and memantine as treatment for acquired nystagmus.
Trial report in Annals of neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 98 citations in OpenAlex.
- Memantine for Multiple Sclerosis: A Systematic Review and Meta-Analysis of Randomized Trials.Frontiers in neurology · 2020Pooled it
- Interventions for visual field defects in people with stroke.The Cochrane database of systematic reviews · 2019Pooled it
- Memantine for the patients with mild cognitive impairment in Parkinson's disease: a pharmacological fMRI study.BMC neurology · 2022Trial
- Upbeat nystagmus: a clinical and pathophysiological review.Frontiers in neurology · 2025Review
- Nystagmus in Clinical Practice: From Diagnosis to Treatment-A Comprehensive Review.Clinical ophthalmology (Auckland, N.Z.) · 2025Review
- Evaluation of Cerebellar Ataxic Patients.Neurologic clinics · 2023Review
- Pharmacological and Behavioral Strategies to Improve Vision in Acquired Pendular Nystagmus.The American journal of case reports · 2022Observational
- A 6-month trial of memantine for nystagmus and associated phenomena in oculopalatal tremor.Frontiers in neurology · 2022Article
- Hyperventilation Increases the Randomness of Ocular Palatal Tremor Waveforms.Cerebellum (London, England) · 2021Article
- Oncologic causes of oculopalatal tremors: neurophysiology and treatment.Acta neurologica Belgica · 2021Review
- Gabapentin and memantine increases randomness of oscillatory waveform in ocular palatal tremor.Journal of computational neuroscience · 2021Article
- Impact of Exercise on Immunometabolism in Multiple Sclerosis.Journal of clinical medicine · 2020Review
- [Hypertrophic olivary degeneration : Cause of new neurological symptoms after stroke].Der Nervenarzt · 2019Article
- Disorders of Vergence Eye Movements.Current treatment options in neurology · 2018Review
- [New aspects of symptomatic MS treatment: Part 4-sexual dysfunction and eye movement disorders].Der Nervenarzt · 2018Review
- Occulomotor Neural Integrator Dysfunction in Multiple Sclerosis: Insights From Neuroimaging.Frontiers in neurology · 2018Article
- Eye Movement Abnormalities in Multiple Sclerosis: Pathogenesis, Modeling, and Treatment.Frontiers in neurology · 2018Review
- Acquired pendular nystagmus.Journal of the neurological sciences · 2017Review
- Hypertrophic Olivary Degeneration and Palatal or Oculopalatal Tremor.Frontiers in neurology · 2017Review
- Diagnostic approach to abnormal spontaneous eye movements.Continuum (Minneapolis, Minn.) · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
We conducted a masked, crossover, therapeutic trial of gabapentin (1,200mg/day) versus memantine (40 mg/day) for acquired nystagmus in 10 patients (aged 28-61 years; 7 female; 3 multiple sclerosis [MS]; 6 post-stroke; 1 post-traumatic). Nystagmus was pendular in 6 patients (4 oculopalatal tremor; 2 MS) and jerk upbeat, hemi-seesaw, torsional, or upbeat-diagonal in each of the others. For the group, both drugs reduced median eye speed (p < 0.001), gabapentin by 32.8% and memantine by 27.8%, and improved visual acuity (p < 0.05). Each patient improved with 1 or both drugs. Side effects included unsteadiness with gabapentin and lethargy with memantine. Both drugs should be considered as treatment for acquired forms of nystagmus.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.