ArticleThe Journal of comparative neurology2010
Bilateral effects of unilateral cochlear implantation in congenitally deaf cats.
Article in The Journal of comparative neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 47 citations in OpenAlex.
- Threshold-distance functions predict speech recognition with cochlear implants.Scientific reports · 2025Article
- Dissociated Representation of Binaural Cues in Single-Sided Deafness: Implications for Cochlear Implantation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Effect of Chronic Stimulation and Stimulus Level on Temporal Processing by Cochlear Implant Listeners.Journal of the Association for Research in Otolaryngology : JARO · 2019Article
- Neural ITD Sensitivity and Temporal Coding with Cochlear Implants in an Animal Model of Early-Onset Deafness.Journal of the Association for Research in Otolaryngology : JARO · 2019Article
- Chronic Deafness Degrades Temporal Acuity in the Electrically Stimulated Auditory Pathway.Journal of the Association for Research in Otolaryngology : JARO · 2018Article
- Congenital deafness affects deep layers in primary and secondary auditory cortex.The Journal of comparative neurology · 2017Article
- Passive stimulation and behavioral training differentially transform temporal processing in the inferior colliculus and primary auditory cortex.Journal of neurophysiology · 2017Article
- Monaural Congenital Deafness Affects Aural Dominance and Degrades Binaural Processing.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Long-term asymmetric hearing affects cochlear implantation outcomes differently in adults with pre- and postlingual hearing loss.PloS one · 2015Article
- Morphological and physiological development of auditory synapses.Hearing research · 2014Review
- Benefits and detriments of unilateral cochlear implant use on bilateral auditory development in children who are deaf.Frontiers in psychology · 2013Review
- Congenital and prolonged adult-onset deafness cause distinct degradations in neural ITD coding with bilateral cochlear implants.Journal of the Association for Research in Otolaryngology : JARO · 2013Article
- Morphological characterization of bushy cells and their inputs in the laboratory mouse (Mus musculus) anteroventral cochlear nucleus.PloS one · 2013Article
- Unilateral hearing during development: hemispheric specificity in plastic reorganizations.Frontiers in systems neuroscience · 2013Article
- Feline deafness.The Veterinary clinics of North America. Small animal practice · 2012Review
- Synaptic plasticity in the medial superior olive of hearing, deaf, and cochlear-implanted cats.The Journal of comparative neurology · 2012Article
- Synaptic morphology and the influence of auditory experience.Hearing research · 2011Review
- The spiral ganglion: connecting the peripheral and central auditory systems.Hearing research · 2011Review
- The effect of cochlear-implant-mediated electrical stimulation on spiral ganglion cells in congenitally deaf white cats.Journal of the Association for Research in Otolaryngology : JARO · 2010Article
- Postnatal development of the endbulb of held in congenitally deaf cats.Frontiers in neuroanatomy · 2010Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Congenital deafness results in synaptic abnormalities in auditory nerve endings. These abnormalities are most prominent in terminals called endbulbs of Held, which are large, axosomatic synaptic endings whose size and evolutionary conservation emphasize their importance. Transmission jitter, delay, or failures, which would corrupt the processing of timing information, are possible consequences of the perturbations at this synaptic junction. We sought to determine whether electrical stimulation of the congenitally deaf auditory system via cochlear implants would restore the endbulb synapses to their normal morphology. Three and 6-month-old congenitally deaf cats received unilateral cochlear implants and were stimulated for a period of 10-19 weeks by using human speech processors. Implanted cats exhibited acoustic startle responses and were trained to approach their food dish in response to a specific acoustic stimulus. Endbulb synapses were examined by using serial section electron microscopy from cohorts of cats with normal hearing, congenital deafness, or congenital deafness with a cochlear implant. Synapse restoration was evident in endbulb synapses on the stimulated side of cats implanted at 3 months of age but not at 6 months. In the young implanted cats, postsynaptic densities exhibited normal size, shape, and distribution, and synaptic vesicles had density values typical of hearing cats. Synapses of the contralateral auditory nerve in early implanted cats also exhibited synapses with more normal structural features. These results demonstrate that electrical stimulation with a cochlear implant can help preserve central auditory synapses through direct and indirect pathways in an age-dependent fashion.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.