ArticleJournal of clinical immunology2010
The polymorphism of IL-17 G-152A was associated with childhood asthma and bacterial colonization of the hypopharynx in bronchiolitis.
Article in Journal of clinical immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- Association between IL-17A, IL-17F and IL-17RA gene polymorphisms and susceptibility to psoriasis and psoriatic arthritis: a meta-analysis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2021Pooled it
- Single-Nucleotide Polymorphisms of IL-17 Gene Are Associated with Asthma Susceptibility in an Asian Population.Medical science monitor : international medical journal of experimental and clinical research · 2016Pooled it
- The -308 G/A polymorphism in TNF-α gene is associated with asthma risk: an update by meta-analysis.Journal of clinical immunology · 2011Pooled it
- The role of IL10 and IL17 gene polymorphisms in treatment response in children and adolescents with severe asthma.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2024Article
- IL12B and IL23R polymorphisms are associated with alopecia areata.Genes and immunity · 2020Article
- Association of interleukin-17a rs2275913 gene polymorphism and asthma risk: a meta-analysis.Archives of medical science : AMS · 2018Review
- Association between rs2275913 single-nucleotide polymorphism of the interleukin-17A gene and perioperative analgesic use in cosmetic orthognathic surgery.Neuropsychopharmacology reports · 2018Article
- Cytokines in sensitization to aeroallergens.Allergologie select · 2018Review
- The association of IL-17A polymorphisms with IL-17A serum levels and risk of ischemic stroke.Oncotarget · 2017Article
- Rapid detection of functional gene polymorphisms of TLRs and IL-17 using high resolution melting analysis.Scientific reports · 2017Article
- The IL-17A rs2275913 single nucleotide polymorphism is associated with protection to tuberculosis but related to higher disease severity in Argentina.Scientific reports · 2017Article
- The Equivocal Role of Th17 Cells and Neutrophils on Immunopathogenesis of Leishmaniasis.Frontiers in immunology · 2017Review
- Polymorphism of IL-10 gene promoter region: association with T cell proliferative responses after acellular pertussis vaccination in adults.Immunogenetics · 2016Article
- Common variants in IL-17A/IL-17RA axis contribute to predisposition to and progression of congestive heart failure.Medicine · 2016Article
- Association between IL17A and IL17F polymorphisms and risk of Henoch-Schonlein purpura in Chinese children.Rheumatology international · 2016Article
- Mucosal-associated invariant T cells in autoimmunity, immune-mediated diseases and airways disease.Immunology · 2016Review
- Environmental Exposure and Genetic Predisposition as Risk Factors for Asthma in China.Allergy, asthma & immunology research · 2016Review
- Molecular Mechanisms of Airway Hyperresponsiveness in a Murine Model of Steroid-Resistant Airway Inflammation.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Association of Vitamin D Receptor Polymorphism with Susceptibility to Symptomatic Pertussis.PloS one · 2016Article
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Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveInterleukin (IL)-17 plays an important role in the pathogenesis of asthma. We investigated the association between single-nucleotide polymorphism (SNP) of IL-17 (rs2275913, IL-17 G-152A) and asthma-related traits. Its effect on IL-17 production was also attractive.
methodsOne hundred and sixty eight childhood asthmatic patients, 144 bronchiolitis patients, and 205 healthy controls were recruited in this study. SNP rs2275913 was genotyped by polymerase chain reaction-restriction fragment length polymorphism. Peripheral blood mononuclear cells (PBMCs) from parts of healthy controls with different genotype were isolated and cultured with phytohaemagglutinin (PHA) for detection of IL-17 in the supernatants.
resultsSNP rs2275913 was associated with asthma (P = 0.03) in genotype frequency test. Children with homozygous A were 2.29 times more likely to have asthma than others (95% confidence interval 1.39-3.78, P = 0.001). The strength of associations was moderately higher by allergy comorbidity. Furthermore, SNP rs2275913 A allele was associated with abnormal lung function and serum total IgE in asthmatics, although the production of IL-17 by PHA-induced PBMC seemed to be not different among individuals with different genotypes. The distribution of SNP rs2275913 in bronchiolitis was marginally statistically different with controls and demonstrated a tendency close to that in asthma. Higher Streptococcus pneumoniae and Moraxella catarrhalis detection rates were shown in bronchiolitis patients with homozygous A allele than those with other genotypes (20.8% vs. 3.7%, P < 0.01 and 20.8% vs. 6.2%, P = 0.03).
conclusionThe preliminary results demonstrate that IL-17 SNP rs2275913 was associated with several asthma-related traits and confers genetic susceptibility to childhood asthma. It may be used to develop markers to assess the risk of asthma, especially in the bronchiolitis population. It may be a potential bridge to connect the bacterial colonization and the onset of asthma.
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