ArticleDigestive diseases and sciences2010
Acid suppression by proton pump inhibitors enhances aquaporin-4 and KCNQ1 expression in gastric fundic parietal cells in mouse.
Article in Digestive diseases and sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 32 citations in OpenAlex.
- Review
- Iron deposition in gastric black spots: Clinicopathological insights and NanoSuit-correlative light and electron microscopy analysis.DEN open · 2025Article
- Validation of a Novel Endoscopic Feature that PredictsThe Korean journal of helicobacter and upper gastrointestinal research · 2023Article
- Article
- Proton pump inhibitor usage is associated with higher all-cause mortality and CV events in peritoneal dialysis patients.Renal failure · 2022Article
- Pathophysiological role of ion channels and transporters in gastrointestinal mucosal diseases.Cellular and molecular life sciences : CMLS · 2021Review
- Marked reduction in the number of white globe appearance lesions in the noncancerous stomach after exchanging vonoprazan for esomeprazole treatment: a follow-up case report.Clinical journal of gastroenterology · 2021Article
- Development of white globe appearance lesions in the noncancerous stomach after vonoprazan administration: a report of two cases with a literature review.Clinical journal of gastroenterology · 2021Review
- The Physiology of the Gastric Parietal Cell.Physiological reviews · 2020Review
- Hypergastrinemia Expands Gastric ECL Cells Through CCK2RCellular and molecular gastroenterology and hepatology · 2020Article
- Gastro-Protective and Anti-Oxidant Potential ofAntioxidants (Basel, Switzerland) · 2019Article
- Omeprazole preserves the RER in chief cells and enhances re-epithelialization of parietal cells with SOD and AQP-4 up-regulation in ethanol-induced gastritis rats.Experimental and therapeutic medicine · 2017Article
- Hemorrhagic polyps formed like fundic gland polyps during long-term proton pump inhibitor administration.Clinical journal of gastroenterology · 2017Article
- Omeprazole promotes carcinogenesis of fore-stomach in mice with co-stimulation of nitrosamine.Oncotarget · 2017Article
- Petroselinum Crispum is Effective in Reducing Stress-Induced Gastric Oxidative Damage.Balkan medical journal · 2017Article
- Changes in the spectrum of gastric polyps in the Chinese population.World journal of gastroenterology · 2015Article
- Unexpected effect of proton pump inhibitors: elevation of the cardiovascular risk factor asymmetric dimethylarginine.Circulation · 2013Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe widespread use of proton pump inhibitors (PPIs) is known to cause sporadic gastric fundic gland polyps (FGPs). Altered expression and localization of the water or ion transport proteins might contribute to the excess fluid secretion into the cystic lumen for the development of FGPs.
aimsWe investigated the alteration of the murine gastric fundic mucosa after PPI treatment, and examined the expression of water channel aquaporin-4 (AQP4) and potassium channel KCNQ1, which are expressed only in the parietal cells in the gastric mucosa.
methodsMale 5-week-old C57BL/6J mice were administered lansoprazole (LPZ) by subcutaneous injection for 8 weeks. The expression of AQP4 and KCNQ1 were investigated by Western blotting, quantitative RT-PCR, and immunohistochemistry. The expression of mucin-6 (Muc6), pepsinogen, and sonic hedgehog (Shh) were also investigated as mucosal cell lineage markers.
resultsGastric mucosal hyperplasia with multiple cystic dilatations, exhibiting similar histological findings to the FGPs, was observed in the LPZ-treated mice. An increase in the number of AQP4-positive parietal cells and KCNQ1-positive parietal cells was observed. The extension of the distribution of AQP4-positive cells toward the surface of the fundic glands was also observed. The expression levels of AQP4 mRNA and protein were significantly enhanced. The expression of KCNQ1 mRNA was correlated with that of AQP4 mRNA in the LPZ-treated mice. Mucous neck-to-zymogenic cell lineage differentiation was delayed in association with decreased expression of Shh in the LPZ-treated mice.
conclusionsPPI administration increased the number of parietal cells with enhanced expression of AQP4 and KCNQ1.
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