ReviewDigestive diseases and sciences2010
The role of sonic hedgehog reemergence during gastric cancer.
Review in Digestive diseases and sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Rutaecarpine Ameliorates Murine N-Methyl-N'-Nitro-N-Nitrosoguanidine-Induced Chronic Atrophic Gastritis by Sonic Hedgehog Pathway.Molecules (Basel, Switzerland) · 2023Article
- Multiscale positive feedbacks contribute to unidirectional gastric disease progression induced by helicobacter pylori infection.BMC systems biology · 2017Article
- Dopamine Burden Induced the Inactivation of Sonic Hedgehog Signaling to Cognitive Decline in Minimal Hepatic Encephalopathy.Aging and disease · 2017Article
- Advances of Molecular Targeted Therapy in Gastric Cancer.Journal of gastrointestinal cancer · 2016Review
- Recapitulating Human Gastric Cancer Pathogenesis: Experimental Models of Gastric Cancer.Advances in experimental medicine and biology · 2016Review
- Interaction between gastric cancer stem cells and the tumor microenvironment.Journal of gastroenterology · 2014Review
- Mesenchymal stromal cells promote tumor progression in fibrosarcoma and gastric cancer cells.Korean journal of pathology · 2014Article
- Sonic hedgehog expression in a rat model of chronic pancreatitis.World journal of gastroenterology · 2014Article
- DNA methylation subgroups and the CpG island methylator phenotype in gastric cancer: a comprehensive profiling approach.BMC gastroenterology · 2014Article
- Gastric cancer stem cells: therapeutic targets.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2014Review
- Crosstalks between cytokines and Sonic Hedgehog in Helicobacter pylori infection: a mathematical model.PloS one · 2014Article
- Cancer stem cells: the 'heartbeat' of gastric cancer.Journal of gastroenterology · 2013Review
- Gastric stem cells and gastric cancer stem cells.Anatomy & cell biology · 2013Article
- Differences in gastric carcinoma microenvironment stratify according to EBV infection intensity: implications for possible immune adjuvant therapy.PLoS pathogens · 2013Article
- Transgenic expression of interferon-γ in mouse stomach leads to inflammation, metaplasia, and dysplasia.The American journal of pathology · 2012Article
- HSulf-1 suppresses cell growth and down-regulates Hedgehog signaling in human gastric cancer cells.Oncology letters · 2011Article
- Hedgehog signaling: networking to nurture a promalignant tumor microenvironment.Molecular cancer research : MCR · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Sonic Hedgehog (Shh) signaling has been extensively studied for its role in developmental biology and cancer biology. The association between Shh and cancer development in general is well established but the functional role of Shh in the development and progression of gastric cancer specifically is largely unknown. Bone marrow-derived stem cells, specifically mesenchymal stem cells (MSCs) infiltrate and engraft into the gastric mucosa in response to the chronic inflammatory environment of Helicobacter infection. In this review, MSC infiltration and changes in the cytokine and cellular profiles of later-stage chronic environments will be tied into their interactions with the Shh pathway. We will discuss how these changes shape tumorigenesis and tumor progression in the gastric mucosa. The current review focuses on the Shh signaling pathway and its role in the development of gastric cancer, specifically in response to Helicobacter pylori infection. We follow with an in-depth discussion of the regulation of the Hedgehog pathway during acute and chronic gastric inflammation with a focus on signaling within the MSC compartment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.