Trial reportClinical autonomic research : official journal of the Clinical Autonomic Research Society2010
Does an acute inflammatory response temporarily attenuate parasympathetic reactivation?
Trial report in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 13 citations in OpenAlex.
- Is the Effect of the COVID-19 Vaccine on Heart Rate Variability Permanent?Medicina (Kaunas, Lithuania) · 2023Observational
- Review
- Cardiovascular autonomic regulation, inflammation and pain in rheumatoid arthritis.Autonomic neuroscience : basic & clinical · 2017Observational
- Factors associated with parasympathetic activation following exercise in patients with rheumatoid arthritis: a cross-sectional study.BMC cardiovascular disorders · 2016Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAlthough observational studies suggest that inflammatory markers are associated with autonomic nervous system function, the causal relationship of this is not clear. We tested the hypothesis that acute inflammation will temporarily attenuate vagal reactivation as measured by heart rate recovery after exercise.
methodsIn this double-blind randomized study, 24 healthy subjects were assigned to receive either an influenza vaccine (n = 15) as a model to generate a systemic inflammatory response or a sham vaccine (n = 9). Heart rate recovery after exercise testing was used as an index of parasympathetic nervous function and was calculated as the difference between maximal heart rate during the test and heart rate 1 and 2 min after cessation of exercise. Both blood analysis and treadmill exercise stress tests were conducted before and 48 h after each vaccination.
resultsInflammatory marker, log C-reactive protein (1.9 +/- 1.2 to 2.8 +/- 1.4, p < 0.05) was significantly increased after the influenza vaccine. Heart rate recovery 1 was significantly attenuated 48 h after the influenza vaccination (23.4 +/- 6.4 to 20.5 +/- 4.9, p < 0.05) but not sham vaccination.
conclusionsThese findings show that acute inflammation is associated with a temporary deterioration in cardiac autonomic nervous system function in healthy subjects.
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Registered trials
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