Trial reportJournal of neural transmission (Vienna, Austria : 1996)2010
Hemifacial spasm and reinnervation synkinesias: long-term treatment with either Botox or Dysport.
Trial report in Journal of neural transmission (Vienna, Austria : 1996), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Efficacy and safety of botulinum neurotoxin in the treatment of hemifacial spasms: a systematic review and meta-analysis.BMC neurology · 2024Pooled it
- Botulinum toxin A treatment in facial palsy synkinesis: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023Pooled it
- Dysport and Botox at a ratio of 2.5:1 units in cervical dystonia: a double-blind, randomized study.Movement disorders : official journal of the Movement Disorder Society · 2015Trial
- Efficacy of isolated periocular botulinum toxin A injections versus periocular and adjunctive lower facial injections in hemifacial spasm: a randomized, controlled, noninferiority, crossover trial.Annals of medicine · 2025Article
- Switox: Retrospective Analysis of Botulinum Toxin Switching in Management of Spasticity.Toxins · 2025Article
- Microvascular decompression for hemifacial spasm after Bell's palsy: a retrospective clinical study.Neurosurgical review · 2024Article
- Long-term follow-up of intravesical abobotulinumtoxinA (Dysport®) injections in women with idiopathic detrusor overactivity.Asian journal of urology · 2024Article
- Preseptal and Pretarsal Botulinum Toxin Injection in Hemifacial Spasm and Blepharospasm: A 10-Year Comparative Study.Therapeutics and clinical risk management · 2023Article
- Antinociceptive Actions of Botulinum Toxin A1 on Immunogenic Hypersensitivity in Temporomandibular Joint of Rats.Toxins · 2022Article
- Review
- Experiences on The Administration of Botulinum Toxin in Movement Disorders.Journal of translational internal medicine · 2021Article
- A practical guide to optimizing the benefits of post-stroke spasticity interventions with botulinum toxin A: An international group consensus.Journal of rehabilitation medicine · 2021Article
- Evaluation of botulinum toxin effects in hemifacial spasm patients: correlation between clinical rating scales and high-speed video system measurements.Journal of neural transmission (Vienna, Austria : 1996) · 2020Article
- Treatment of Blepharospasm/Hemifacial Spasm.Current treatment options in neurology · 2017Review
- Long-term treatment of chronic migraine with OnabotulinumtoxinA: efficacy, quality of life and tolerability in a real-life setting.Journal of neural transmission (Vienna, Austria : 1996) · 2016Article
- Review
- Blepharospasm: long-term treatment with either Botox®, Xeomin® or Dysport®.Journal of neural transmission (Vienna, Austria : 1996) · 2015Article
- Systematic Literature Review of AbobotulinumtoxinA in Clinical Trials for Blepharospasm and Hemifacial Spasm.Tremor and other hyperkinetic movements (New York, N.Y.) · 2015Review
- Botulinum toxin in hemifacial spasm: the challenge to assess the effect of treatment.Journal of neural transmission (Vienna, Austria : 1996) · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Botulinum toxin is considered the treatment of choice for hemifacial spasm (HFS) and reinnervation synkinesias (RS). We present 133 patients with HFS (n = 97) and RS (n = 36) who have been treated with either Botox (n = 78) or Dysport (n = 55) exclusively for 6 years (range 2-12 years). The Botox dose was 21 +/- 8 MU, the Dysport dose 46 +/- 22 MU. The therapeutic effect started after 7.1 +/- 2.3 days and lasted for 12.5 +/- 3.9 weeks. It was stable throughout the observation period in 85% of all patients. Adverse effects occurred in 5.4% of injection series. No patient terminated treatment because of unsatisfactory results. Secondary therapy failure did not occur. With an effective conversion ratio of Botox:Dysport = 1:2.56 there were no differences between both drugs with respect to therapeutic efficacy and adverse effects thus confirming the hypothesis that there may not be intrinsic differences between both products.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.