ArticleJournal of molecular evolution2010
Circadian input kinases and their homologs in cyanobacteria: evolutionary constraints versus architectural diversification.
Article in Journal of molecular evolution, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Endogenous clock-mediated regulation of intracellular oxygen dynamics is essential for diazotrophic growth of unicellular cyanobacteria.Nature communications · 2024Article
- Evolution of kaiA, a key circadian gene of cyanobacteria.Scientific reports · 2021Article
- The Circadian Clock-A Molecular Tool for Survival in Cyanobacteria.Life (Basel, Switzerland) · 2020Review
- For Whom the Clock Ticks: Clinical Chronobiology for Infectious Diseases.Frontiers in immunology · 2020Review
- Minimal tool set for a prokaryotic circadian clock.BMC evolutionary biology · 2017Article
- Article
- Giving Time Purpose: The Synechococcus elongatus Clock in a Broader Network Context.Annual review of genetics · 2015Review
- Single mutations in sasA enable a simpler ΔcikA gene network architecture with equivalent circadian properties.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Evolution of PAS domains and PAS-containing genes in eukaryotes.Chromosoma · 2014Article
- Patterns of nucleotide diversity of the ldpA circadian gene in closely related species of cyanobacteria from extreme cold deserts.Applied and environmental microbiology · 2013Article
- Extreme conservation and non-neutral evolution of the cpmA Circadian locus in a globally distributed Chroococcidiopsis sp. from naturally stressful habitats.Molecular biology and evolution · 2012Article
- Simplicity and complexity in the cyanobacterial circadian clock mechanism.Current opinion in genetics & development · 2010Review
- Circadian clock proteins in prokaryotes: hidden rhythms?Frontiers in microbiology · 2010Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The circadian input kinase A (cikA) gene encodes a protein relaying environmental signal to the central circadian oscillator in cyanobacteria. The CikA protein has a variable architecture and usually consists of four tandemly arrayed domains: GAF, histidine kinase (HisKA), histidine kinase-like ATPase (HATPase_c), and a pseudo-receiver (REC). Among them, HisKA and HATPase_c are the least polymorphic, and REC is not present in heterocystic filamentous cyanobacteria. CikA contains several conserved motifs that are likely important for circadian function. There are at least three types of circadian systems, each of which possesses a different set of circadian genes. The originally described circadian system (kaiABC system) possesses both cikA and kaiA, while the others lack either only cikA (kaiABC (Delta)) or both (kaiBC). The results we obtained allowed us to approximate the time of the cikA origin to be about 2600-2200 MYA and the time of its loss in the species with the kaiABC (Delta) or kaiBC system between 1100 and 600 MYA. Circadian specialization of CikA, as opposed to its non-circadian homologs, is a result of several factors, including the unique conserved domain architecture and high evolutionary constraints of some domains and regions, which were previously identified as critical for the circadian function of the gene.
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