Evidence map›Paper›PMID 20437026›Full record

Trial reportDiabetologia2010

The relationship of retinal vessel diameter to changes in diabetic nephropathy structural variables in patients with type 1 diabetes.

R Klein, M D Knudtson, B E K Klein, B Zinman, R Gardiner, S Suissa, A R Sinaiko, S M Donnelly, P Goodyer, T Strand and 1 more

Abstract readClinical TrialMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetologia, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Microvascular changes at different stages of chronic kidney disease.Journal of clinical hypertension (Greenwich, Conn.) · 2021
    Article
  13. Article
  14. Review
  15. Adaptive optics imaging of the human retina.Progress in retinal and eye research · 2019
    Review
  16. Article
  17. Observational
  18. Article
  19. Shiftwork and the Retinal Vasculature Diameters Among Police Officers.Journal of occupational and environmental medicine · 2017
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

R KleinDepartment of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, 610 North Walnut Street, Fourth Floor WARF, Madison, WI 53726-2397, USA. kleinr@epi.ophth.wisc.edu
M D Knudtson
B E K Klein
B Zinman
R Gardiner
S Suissa
A R Sinaiko
S M Donnelly
P Goodyer
T Strand
M Mauer

Funding

YOUTH DRUG ABUSE, ADHD, AND RELATED DISRUPTIVE DISORDERSM01RR000400 · NCRR · UNIVERSITY OF MINNESOTA TWIN CITIES · PI BACHANOVA, VERONIKA S · 1985 to 2009
$33.7M
Renin Angiotensin System Blockage-DN (RASS)R01DK051975 · NIDDK · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MAUER, S MICHAEL · 1997 to 2007
$7.0M
EPIDEMIOLOGY OF DIABETIC RETINOPATHYR03EY012198 · NEI · UNIVERSITY OF WISCONSIN MADISON · PI KLEIN, RONALD · 1998 to 1999
–
CIHR DCT 14281NCRR NIH HHS M01 RR000400NCRR NIH HHS M01 RR 00400NEI NIH HHS EY12198NEI NIH HHS R03 EY012198NIDDK NIH HHS DK51975NIDDK NIH HHS R01 DK051975
6 · The paper itself

Abstract

aims/hypothesisWe examined whether retinal vessel diameter in persons with type 1 diabetes mellitus is associated with changes in subclinical anatomical and functional indicators of diabetic nephropathy.

methodsPersons with type 1 diabetes mellitus had gradable fundus photographs and renal biopsy data at baseline and 5-year follow-up (n = 234). Retinal arteriolar and venular diameters were measured at baseline and follow-up. Central retinal arteriole equivalent (CRAE) and central retinal venule equivalent (CRVE) were computed. Baseline and 5-year follow-up renal structural variables were assessed by masked electron microscopic morphometric analyses from percutaneous renal biopsy specimens. Variables assessed included: mesangial fractional volume, glomerular basement membrane width, mesangial matrix fractional volume and glomerular basement membrane width composite glomerulopathy index.

resultsWhile controlling for other covariates, baseline CRAE was positively associated with change in the glomerulopathy index over the 5-year period. Change in CRAE was inversely related to a change in mesangial matrix fractional volume and abnormal mesangial matrix fractional volume, while change in CRVE was directly related to change in the volume fraction of cortex that was interstitium [Vv((Int/cortex))] over the 5-year period. Baseline CRAE or CRVE or changes in these diameters were not related to changes in other anatomical or functional renal endpoints. CONCLUSIONS/

interpretationIndependently of other factors, baseline CRAE correlated with changes in glomerulopathy index, a composite measure of extracellular matrix accumulation in the mesangium and glomerular basement membrane. A narrowing of the CRAE was related to mesangial matrix accumulation. Changes in CRVE were related to changes in Vv((Int/cortex),) a measure of interstitial expansion in persons with type 1 diabetes mellitus.

Indexed as

AdolescentAdultAnalysis of VarianceDiabetes Mellitus, Type 1Diabetic NephropathiesDouble-Blind MethodFemaleHumansKidneyLogistic ModelsMaleMiddle AgedRetinal Vessels

Identifiers

PMID20437026
PMCPMC2892559

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.