ArticleOrganic & biomolecular chemistry2010
Small molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex.
Article in Organic & biomolecular chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 109 citations in OpenAlex.
- Profiling RNA G-Quadruplexes In vivo.Current protocols · 2025Article
- RNA G-quadruplex structure targeting and imaging: recent advances and future directions.RNA (New York, N.Y.) · 2025Review
- Low-Molecular Weight Small Molecules Can Potently Bind RNA and Affect Oncogenic Pathways in Cells.Journal of the American Chemical Society · 2022Article
- Review
- A Key Molecular Regulator, RNA G-Quadruplex and Its Function in Plants.Frontiers in plant science · 2022Review
- Triazolyl Dibenzo[Asian journal of organic chemistry · 2021Article
- Quadruplex Ligands in Cancer Therapy.Cancers · 2021Review
- Targeting RNA with small molecules: from fundamental principles towards the clinic.Chemical Society reviews · 2021Review
- Stabilization of human telomeric RNA G-quadruplex by the water-compatible optically pure and biologically-active metallohelices.Scientific reports · 2020Article
- RNA G-quadruplex structures exist and function in vivo in plants.Genome biology · 2020Article
- Genome-Wide Discovery of G-Quadruplexes in Wheat: Distribution and Putative Functional Roles.G3 (Bethesda, Md.) · 2020Article
- Regulating Divergent Transcriptomes through mRNA Splicing and Its Modulation Using Various Small Compounds.International journal of molecular sciences · 2020Review
- G-quadruplex located in the 5'UTR of the BAG-1 mRNA affects both its cap-dependent and cap-independent translation through global secondary structure maintenance.Nucleic acids research · 2019Article
- Small-Molecule-Targeting Hairpin Loop of hTERT Promoter G-Quadruplex Induces Cancer Cell Death.Cell chemical biology · 2019Article
- Unveiling the druggable RNA targets and small molecule therapeutics.Bioorganic & medicinal chemistry · 2019Review
- A high-throughput screen identifies small molecule modulators of alternative splicing by targeting RNA G-quadruplexes.Nucleic acids research · 2019Article
- Octa-repeat domain of the mammalian prion protein mRNA forms stable A-helical hairpin structure rather than G-quadruplexes.Scientific reports · 2019Article
- Soluble Siglec-14 glycan-recognition protein is generated by alternative splicing and suppresses myeloid inflammatory responses.The Journal of biological chemistry · 2018Article
- Article
- eIF4A alleviates the translational repression mediated by classical secondary structures more than by G-quadruplexes.Nucleic acids research · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Herein, we show that a naturally occurring RNA G-quadruplex element within the 5' UTR of the human NRAS proto-oncogene is a target for a small molecule that inhibits translation in vitro. The present study provides a first demonstration that natural 5' UTR mRNA G-quadruplexes have potential as molecular targets for small molecules that modulate translation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.