ArticleProceedings of SPIE--the International Society for Optical Engineering2009
Engineering New Aptamer Geometries for Electrochemical Aptamer-Based Sensors.
Article in Proceedings of SPIE--the International Society for Optical Engineering, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- On the Design, Fabrication, and Operation of Electrochemical Aptamer-Based Sensors.ACS sensors · 2025Review
- Ionic Strength and Hybridization Position near Gold Electrodes Can Significantly Improve Kinetics in DNA-Based Electrochemical Sensors.ACS applied materials & interfaces · 2023Article
- Conformational Changes of Immobilized Polythymine due to External Stressors Studied with Temperature-Controlled Electrochemical Microdevices.Langmuir : the ACS journal of surfaces and colloids · 2021Article
- Reagentless, Structure-Switching, Electrochemical Aptamer-Based Sensors.Annual review of analytical chemistry (Palo Alto, Calif.) · 2016Article
- Heterogeneous Electrochemical Aptamer-Based Sensor Surfaces for Controlled Sensor Response.Langmuir : the ACS journal of surfaces and colloids · 2015Article
- Rationally designing aptamer sequences with reduced affinity for controlled sensor performance.Sensors (Basel, Switzerland) · 2015Article
- Switch-based biosensors: a new approach towards real-time, in vivo molecular detection.Trends in biotechnology · 2011Article
- A mechanistic study of electron transfer from the distal termini of electrode-bound, single-stranded DNAs.Journal of the American Chemical Society · 2010Article
- Biomimetic glass nanopores employing aptamer gates responsive to a small molecule.Chemical communications (Cambridge, England) · 2010Article
- Re-engineering aptamers to support reagentless, self-reporting electrochemical sensors.The Analyst · 2010Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Electrochemical aptamer-based sensors (E-AB sensors) represent a promising new approach to the detection of small molecules. E-AB sensors comprise an aptamer that is attached at one end to an electrode surface. The distal end of the aptamer probed is modified with an electroactive redox marker for signal transduction. Herein we report on the optimization of a cocaine-detecting E-AB sensor via optimization of the geometry of the aptamer. We explore two new aptamer architectures, one in which we concatenate three cocaine aptamers into a poly-aptamer and a second in which we divide the cocaine aptamer into pieces connected via an unstructured, 60-thymine linker. Both of these structures are designed such that the reporting redox tag will be located farther from the electrode in the unfolded, target-free conformation. Consistent with this, we find that signal gains of these two constructs are two to three times higher than that of the original E-AB architecture. Likewise all three architectures are selective enough to deploy directly in complex sample matrices, such as undiluted whole blood, with all three sensors successfully detecting the presence of cocaine. The findings in this ongoing study should be of value in future efforts to optimize the signaling of electrochemical aptamer-based sensors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.