ArticlePloS one2010
Initial fitness recovery of HIV-1 is associated with quasispecies heterogeneity and can occur without modifications in the consensus sequence.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed.
- Genetic diversity accelerates canine distemper virus adaptation to ferrets.Journal of virology · 2024Article
- An in vitro workflow to create and modify infectious clones using replication cycle reaction.Virology · 2023Article
- Adaptive value of foot-and-mouth disease virus capsid substitutions with opposite effects on particle acid stability.Scientific reports · 2021Article
- Genetic diversity through social heterosis can increase virulence in RNA viral infections and cancer progression.Royal Society open science · 2021Article
- Have Cells Harboring the HIV Reservoir Been Immunoedited?Frontiers in immunology · 2019Article
- Lethal mutagenesis of an RNA plant virus via lethal defection.Scientific reports · 2018Article
- Differences in adaptive dynamics determine the success of virus variants that propagate together.Virus evolution · 2018Article
- Evolution in spatially mixed host environments increases divergence for evolved fitness and intrapopulation genetic diversity in RNA viruses.Virus evolution · 2016Article
- The number and genetic relatedness of transmitted/founder virus impact clinical outcome in vaginal R5 SHIVSF162P3N infection.Retrovirology · 2014Article
- Realistic three dimensional fitness landscapes generated by self organizing maps for the analysis of experimental HIV-1 evolution.PloS one · 2014Article
- High genetic diversity and adaptive potential of two simian hemorrhagic fever viruses in a wild primate population.PloS one · 2014Article
- Rethinking quasispecies theory: From fittest type to cooperative consortia.World journal of biological chemistry · 2013Review
- Biased mutational pattern and quasispecies hypothesis in H5N1 virus.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2013Article
- Viral fitness: definitions, measurement, and current insights.Current opinion in virology · 2012Review
- Viral population dynamics and virulence thresholds.Current opinion in microbiology · 2012Review
- Viral quasispecies evolution.Microbiology and molecular biology reviews : MMBR · 2012Review
- Article
- Dynamics of in vitro fitness recovery of HIV-1.Journal of virology · 2011Article
- Host alternation of chikungunya virus increases fitness while restricting population diversity and adaptability to novel selective pressures.Journal of virology · 2011Article
- Whole-genome characterization of human and simian immunodeficiency virus intrahost diversity by ultradeep pyrosequencing.Journal of virology · 2010Article
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundFitness recovery of HIV-1 "in vitro" was studied using viral clones that had their fitness decreased as a result of plaque-to-plaque passages. PRINCIPAL
findingsAfter ten large population passages, the viral populations showed an average increase of fitness, although with wide variations among clones. While 5 clones showed significant fitness increases, 3 clones showed increases that were only marginally significant (p<0.1), and 4 clones did not show any change. Fitness recovery was not accompanied by an increase in p24 production, but was associated with an increase in viral titer. Few mutations (an average of 2 mutations per genome) were detected in the consensus nucleotide sequence of the entire genome in all viral populations. Five of the populations did not fix any mutation, and three of them displayed marginally significant fitness increases, illustrating that fitness recovery can occur without detectable alterations of the consensus genomic sequence. The investigation of other possible viral factors associated with the initial steps of fitness recovery, showed that viral quasispecies heterogeneity increased between the initial clones and the passaged populations. A direct statistical correlation between viral heterogeneity and viral fitness was obtained.
conclusionsThus, the initial fitness recovery of debilitated HIV-1 clones was mediated by an increase in quasispecies heterogeneity. This observation, together with the invariance of the consensus sequence despite fitness increases demonstrates the relevance of quasispecies heterogeneity in the evolution of HIV-1 in cell culture.
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