Lentiviral vector gene therapy: effective and safe?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

25 citing papers in PubMed.

1. Multiplexed shRNA-miRs as a candidate for anti HIV-1 therapy: strategies, challenges, and future potential.Journal, genetic engineering & biotechnology · 2022
   Review
2. BET-Independent Murine Leukemia Virus Integration Is RetargetedMicrobiology spectrum · 2022
   Article
3. Suppression of Choroidal Neovascularization by AAV-Based Dual-Acting Antiangiogenic Gene Therapy.Molecular therapy. Nucleic acids · 2019
   Article
4. Genome engineering: a new approach to gene therapy for neuromuscular disorders.Nature reviews. Neurology · 2017
   Review
5. Multiple Sclerosis Gene Therapy with Recombinant Viral Vectors: Overexpression of IL-4, Leukemia Inhibitory Factor, and IL-10 in Wharton's Jelly Stem Cells Used in EAE Mice Model.Cell journal · 2017
   Article
6. Chimeric antigen receptor engineered stem cells: a novel HIV therapy.Immunotherapy · 2017
   Review
7. Modified mRNA as a therapeutic tool to induce cardiac regeneration in ischemic heart disease.Wiley interdisciplinary reviews. Systems biology and medicine · 2017
   Review
8. Achieving HIV-1 Control through RNA-Directed Gene Regulation.Genes · 2016
   Review
9. Recent advances in RNAi-based strategies for therapy and prevention of HIV-1/AIDS.Advanced drug delivery reviews · 2016
   Review
10. Theoretical Approaches to Lentiviral Mediated Neurotrophin Delivery in Potential Treatments of Parkinson's Disease.The Yale journal of biology and medicine · 2016
    Review
11. Converting cell fates: generating hematopoietic stem cells de novo via transcription factor reprogramming.Annals of the New York Academy of Sciences · 2016
    Review
12. Making a Hematopoietic Stem Cell.Trends in cell biology · 2016
    Review
13. Sendai virus, an RNA virus with no risk of genomic integration, delivers CRISPR/Cas9 for efficient gene editing.Molecular therapy. Methods & clinical development · 2016
    Article
14. An international effort to cure a global health problem: A report on the 19th Hemoglobin Switching Conference.Experimental hematology · 2015
    Review
15. RNA interference approaches for treatment of HIV-1 infection.Genome medicine · 2015
    Article
16. Multiplex CRISPR/Cas9-based genome engineering from a single lentiviral vector.Nucleic acids research · 2014
    Article
17. Using Del-1 to tip the angiogenic balance in endothelial cells in modular constructs.Tissue engineering. Part A · 2014
    Article
18. Epigenetic regulatory elements associate with specific histone modifications to prevent silencing of telomeric genes.Nucleic acids research · 2014
    Article
19. Treatment of Hemophilia A in Utero and Postnatally using Sheep as a Model for Cell and Gene Delivery.Journal of genetic syndromes & gene therapy · 2012
    Article
20. Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity.Frontiers of medicine · 2011
    Review

Corrections and comments

• Commented on by
  Assessing the risk of T-cell malignancies in mouse models of SCID-X1.2010

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as