ArticleNature neuroscience2010
C. elegans phototransduction requires a G protein-dependent cGMP pathway and a taste receptor homolog.
Article in Nature neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 130 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
130 citing papers in PubMed, 208 citations in OpenAlex.
- ThebioRxiv : the preprint server for biology · 2026Article
- Automated analysis of C. elegans behavior by LabGym: an open-source, AI-powered platform.G3 (Bethesda, Md.) · 2026Article
- Light sensing enhances thermotolerance and competitive fitness via serotonergic signaling in an eyeless organism.Cell research · 2026Article
- LITE-1 Photoreceptor Mediates Light-Induced Reversal of Ivermectin Paralysis inmicroPublication biology · 2026Article
- Automated analysis ofbioRxiv : the preprint server for biology · 2025Article
- Roles of Cyclic Nucleotide Phosphodiesterases in Signal Transduction Pathways in the NematodeCells · 2025Review
- Evolution of lateralized gustation in nematodes.eLife · 2025Article
- Neurons and molecules involved in noxious light sensation in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2025Article
- A structural perspective on insect gustatory receptors.Chemical senses · 2025Review
- Deep learning-based aberration compensation improves contrast and resolution in fluorescence microscopy.Nature communications · 2025Article
- Phosphodiesterases RegulatemicroPublication biology · 2025Article
- Characterization of auditory sensation inBiophysics reports · 2024Article
- C. elegans PPEF-type phosphatase (Retinal degeneration C ortholog) functions in diverse classes of cilia to regulate nematode behaviors.Scientific reports · 2024Article
- Hierarchical regulation of functionally antagonistic neuropeptides expressed in a single neuron pair.Nature communications · 2024Article
- cGMP-dependent pathway and a GPCR kinase are required for photoresponse in the nematode Pristionchus pacificus.PLoS genetics · 2024Article
- Sensory integration of food and population density during the diapause exit decision involves insulin-like signaling inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- TWISP: a transgenic worm for interrogating signal propagation in Caenorhabditis elegans.Genetics · 2024Article
- Inhibition of a cyclic nucleotide-gated channel on neuronal cilia activates unfolded protein response in intestinal cells to promote longevity.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Sensory integration of food availability and population density during the diapause exit decision involves insulin-like signaling inbioRxiv : the preprint server for biology · 2024Article
- G protein-coupled receptor-based thermosensation determines temperature acclimatization of Caenorhabditis elegans.Nature communications · 2024Article
70 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 4 countries.
Funding
Abstract
The eyeless animal C. elegans is able to sense light and engages in phototaxis behavior that is mediated by photoreceptor cells. However, the molecular and cellular mechanisms underlying phototransduction in C. elegans remain largely unclear. By recording the photoreceptor neuron ASJ in wild-type and various mutant worms, we found that phototransduction in ASJ is a G protein-mediated process and requires membrane-associated guanylate cyclases, but not typical phosphodiesterases. In addition, we found that C. elegans phototransduction requires LITE-1, a candidate photoreceptor protein known to be a member of the invertebrate taste receptor family. Our genetic, pharmacological and electrophysiological data suggest a model in which LITE-1 transduces light signals in ASJ via G protein signaling, which leads to upregulation of the second messenger cGMP, followed by opening of cGMP-sensitive CNG channels and stimulation of photoreceptor cells. Our results identify a phototransduction cascade in C. elegans and implicate the function of a 'taste receptor' in phototransduction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.