ArticleCell cycle (Georgetown, Tex.)2010
Substrate degradation by the anaphase promoting complex occurs during mitotic slippage.
Article in Cell cycle (Georgetown, Tex.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 35 citations in OpenAlex.
- Beyond Death: Unmasking the Intricacies of Apoptosis Escape.Molecular diagnosis & therapy · 2024Review
- CDC20-Mediated hnRNPU Ubiquitination Regulates Chromatin Condensation and Anti-Cancer Drug Response.Cancers · 2022Article
- TORC1 inactivation promotes APC/C-dependent mitotic slippage in yeast and human cells.iScience · 2022Article
- Uncoupling of Mitosis and Cytokinesis Upon a Prolonged Arrest in Metaphase Is Influenced by Protein Phosphatases and Mitotic Transcription in Fission Yeast.Frontiers in cell and developmental biology · 2022Article
- Article
- Polyploidy in liver development, homeostasis and disease.Nature reviews. Gastroenterology & hepatology · 2020Review
- ATP depletion during mitotic arrest induces mitotic slippage and APC/CExperimental & molecular medicine · 2018Article
- Inner centromere localization of the CPC maintains centromere cohesion and allows mitotic checkpoint silencing.Nature communications · 2017Article
- Proteasome inhibition enhances the efficacy of volasertib-induced mitotic arrest in AML in vitro and prolongs survival in vivo.Oncotarget · 2017Article
- Review
- The ubiquitin ligase CRL2ZYG11 targets cyclin B1 for degradation in a conserved pathway that facilitates mitotic slippage.The Journal of cell biology · 2016Article
- Slip slidin' away of mitosis with CRL2Zyg11.The Journal of cell biology · 2016Article
- Identification of genes that are essential to restrict genome duplication to once per cell division.Oncotarget · 2016Article
- PKCι depletion initiates mitotic slippage-induced senescence in glioblastoma.Cell cycle (Georgetown, Tex.) · 2015Article
- Sequestration of CDH1 by MAD2L2 prevents premature APC/C activation prior to anaphase onset.The Journal of cell biology · 2013Article
- Aurora B prevents delayed DNA replication and premature mitotic exit by repressing p21(Cip1).Cell cycle (Georgetown, Tex.) · 2013Article
- Endoreplication.Cold Spring Harbor perspectives in biology · 2013Review
- Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance.Oncotarget · 2012Review
- APC/C-Cdh1-dependent anaphase and telophase progression during mitotic slippage.Cell division · 2012Article
- "The Octet": Eight Protein Kinases that Control Mammalian DNA Replication.Frontiers in physiology · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Microtubule targeting drugs are successful in chemotherapy because they indefinitely activate the spindle assembly checkpoint. The spindle assembly checkpoint monitors proper attachment of all kinetochores to microtubules and tension between the kinetochores of sister chromatids to prevent premature anaphase entry. To this end, the activated spindle assembly checkpoint suppresses the E3 ubiquitin ligase activity of the anaphase-promoting complex (APC). In the continued presence of conditions that activate the spindle assembly checkpoint, cells eventually escape from mitosis by "slippage". It has not been directly tested whether APC activation accompanies slippage. Using cells blocked in mitosis with the microtubule assembly inhibitor nocodazole, we show that mitotic APC substrates are degraded upon mitotic slippage. To confirm that APC is normally activated upon mitotic slippage we have found that knockdown of Cdc20 and Cdh1, two mitotic activators of APC, prevents the degradation of APC substrates during mitotic slippage. We provide the first direct demonstration that despite conditions that activate the spindle checkpoint, APC is indeed activated upon mitotic slippage of cells to interphase cells. Activation of the spindle checkpoint by microtubule targeting drugs used in chemotherapy may not indefinitely prevent APC activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.