ArticleJournal of lipid research2010
Insulin sensitivity regulates cholesterol metabolism to a greater extent than obesity: lessons from the METSIM Study.
Article in Journal of lipid research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Pooled it
- Non-cholesterol sterol levels predict hyperglycemia and conversion to type 2 diabetes in Finnish men.PloS one · 2013Pooled it
- Strawberries Improve Insulin Resistance and Related Cardiometabolic Markers in Adults with Prediabetes: A Randomized Controlled Crossover Trial.The Journal of nutrition · 2025Trial
- Trial
- A 12-week cycling program improves glucose homeostasis, lipid profile, and body composition in women with insulin resistance: a pilot study.Nagoya journal of medical science · 2025Article
- Impact of Graves' hyperthyroidism treatment on lipid profiles and cholesterol dynamics: a prospective observational study.Therapeutic advances in endocrinology and metabolism · 2025Article
- Novel Wild-TypeMicroorganisms · 2024Article
- Pregnancy Cholesterol Metabolism Markers and the Risk of Gestational Diabetes Mellitus: A Nested Case-Control Study.Nutrients · 2023Article
- Mitigation of Insulin Resistance by Natural Products from a New Class of Molecules, Membrane-Active Immunomodulators.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Eggs: Healthy or Risky? A Review of Evidence from High Quality Studies on Hen's Eggs.Nutrients · 2023Review
- Mechanism of the Regulation of Plasma Cholesterol Levels by PI(4,5)PAdvances in experimental medicine and biology · 2023Article
- MicroRNA global profiling in cystic fibrosis cell lines reveals dysregulated pathways related with inflammation, cancer, growth, glucose and lipid metabolism, and fertility: an exploratory study.Acta bio-medica : Atenei Parmensis · 2022Article
- Associations among serum insulin, calprotectin, and C-reactive protein concentrations in Miniature Schnauzers with idiopathic hyperlipidemia before and after feeding an ultra-low-fat diet.Journal of veterinary internal medicine · 2022Article
- Optimizing treatment goals for long-term health outcomes among patients with type 2 diabetes mellitus.BMJ open diabetes research & care · 2021Article
- Motif-Raptor: a cell type-specific and transcription factor centric approach for post-GWAS prioritization of causal regulators.Bioinformatics (Oxford, England) · 2021Article
- CXCL2 Impairs Functions of Bone Marrow Mesenchymal Stem Cells and Can Serve as a Serum Marker in High-Fat Diet-Fed Rats.Frontiers in cell and developmental biology · 2021Article
- Markers of cholesterol synthesis are elevated in adolescents and young adults with type 2 diabetes.Pediatric diabetes · 2020Article
- Plasma metabolites associated with homeostatic model assessment of insulin resistance: metabolite-model design and external validation.Scientific reports · 2019Article
- Proteomic biomarkers of cognitive impairment in obstructive sleep apnea syndrome.Sleep & breathing = Schlaf & Atmung · 2019Article
- An update on the pathogenesis of cholesterol gallstone disease.Current opinion in gastroenterology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cholesterol synthesis is upregulated and absorption downregulated in insulin resistance and in type 2 diabetes. We investigated whether alterations in cholesterol metabolism are observed across the glucose tolerance status, from normoglycemia through impaired glucose tolerance to type 2 diabetes, in 781 randomly selected men 45 to 70 years of age from a population-based Metabolic Syndrome in Men Study. Cholesterol metabolism was assayed using surrogate serum markers, squalene, and noncholesterol sterols. The study population was classified into subgroups according to glucose tolerance as follows: normoglycemia, impaired fasting glucose, impaired glucose tolerance, and type 2 diabetes. LDL cholesterol did not differ between the groups. Cholesterol synthesis markers were lowest and absorption markers highest in normoglycemia. Sitosterol was lower in subjects with impaired fasting glucose compared with normoglycemic subjects (113 +/- 7 vs. 136 +/- 3 10(2) mumol/mmol of cholesterol, P < 0.05). LDL cholesterol was not associated with lathosterol/sitosterol ratio, a marker of cholesterol metabolism. Peripheral insulin sensitivity evaluated by the Matsuda index was associated with the lathosterol/sitosterol ratio in the entire population (r = -0.457, P < 0.001) and with that of lathosterol/cholestanol independently of obesity. In conclusion, cholesterol metabolism was altered already from subjects with impaired fasting glucose. Upregulated cholesterol synthesis was associated with peripheral insulin resistance independent of obesity.
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