ArticleAmerican journal of physiology. Heart and circulatory physiology2010
Mitochondrial KATP channel inhibition blunts arrhythmia protection in ischemic exercised hearts.
Article in American journal of physiology. Heart and circulatory physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Mechanisms Involved in Exercise-Induced Cardioprotection: A Systematic Review.Arquivos brasileiros de cardiologia · 2015Pooled it
- Exercise-induced cardioprotection: From endogenous to exogenous mechanisms.Sports medicine and health science · 2025Review
- Role of miR-133/Dio3 Axis in the T3-Dependent Modulation of Cardiac mitoK-ATP Expression.International journal of molecular sciences · 2022Article
- Short-term exercise-induced protection of cardiovascular function and health: why and how fast does the heart benefit from exercise?The Journal of physiology · 2022Review
- The effect of preconditioning with high-intensity training on tissue levels of G-CSF, its receptor and C-kit after an acute myocardial infarction in male rats.BMC cardiovascular disorders · 2020Article
- Exercise and Cardioprotection: A Natural Defense Against Lethal Myocardial Ischemia-Reperfusion Injury and Potential Guide to Cardiovascular Prophylaxis.Journal of cardiovascular pharmacology and therapeutics · 2019Review
- Exercise: Teaching myocytes new tricks.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Review
- Article
- Mitochondria in the middle: exercise preconditioning protection of striated muscle.The Journal of physiology · 2016Review
- Exercise-induced protection against reperfusion arrhythmia involves stabilization of mitochondrial energetics.American journal of physiology. Heart and circulatory physiology · 2016Article
- Article
- Mechanisms of exercise-induced cardioprotection.Physiology (Bethesda, Md.) · 2014Review
- Exercise and cardiac preconditioning against ischemia reperfusion injury.Current cardiology reviews · 2013Review
- CYP2J2 overexpression protects against arrhythmia susceptibility in cardiac hypertrophy.PloS one · 2013Article
- Article
- Reactive oxygen species are not a required trigger for exercise-induced late preconditioning in the rat heart.American journal of physiology. Regulatory, integrative and comparative physiology · 2012Article
- Ischemia reperfusion injury, KATP channels, and exercise-induced cardioprotection against apoptosis.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Article
- Evaluation of arrhythmia scoring systems and exercise-induced cardioprotection.Medicine and science in sports and exercise · 2012Article
- Exercise and the cardiovascular system.Cardiology research and practice · 2012Article
- Short-term exercise provides left ventricular myocardial protection against intermittent hypoxia-induced apoptosis in rats.European journal of applied physiology · 2011Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The mechanisms responsible for anti-arrhythmic protection during ischemia-reperfusion (IR) in exercised hearts are not fully understood. The purpose of this investigation was to examine whether the ATP-sensitive potassium channels in the mitochondria (mito K(ATP)) and sarcolemma (sarc K(ATP)) provide anti-arrhythmic protection in exercised hearts during IR. Male Sprague-Dawley rats were randomly assigned to cardioprotective treadmill exercise or sedentary conditions before IR (I = 20 min, R = 30 min) in vivo. Subsets of exercised animals received pharmacological inhibitors for mito K(ATP) (5-hydroxydecanoate) or sarc K(ATP) (HMR1098) before IR. Blinded analysis of digital ECG tracings revealed that mito K(ATP) inhibition blunted the anti-arrhythmic effects of exercise, while sarc K(ATP) inhibition did not. Endogenous antioxidant enzyme activities for total, CuZn, and Mn superoxide dismutase, catalase, and glutathione peroxidase from ischemic and perfused ventricular tissue were not mitigated by IR, although oxidative stress was elevated in sedentary and mito K(ATP)-inhibited hearts from exercised animals. These findings suggest that the mito K(ATP) channel provides anti-arrhythmic protection as part of exercise-mediated cardioprotection against IR. Furthermore, these data suggest that the observed anti-arrhythmic protection may be associated with preservation of redox balance in exercised hearts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.