ArticleNucleic acids research2010
Two distinct overstretched DNA states.
Article in Nucleic acids research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed.
- Force-induced melting and S-DNA pathways for DNA overstretching exhibit distinct kinetics.Nucleic acids research · 2025Article
- Cisplatin fastens chromatin irreversibly even at a high chloride concentration.Nucleic acids research · 2021Article
- GC-Content Dependence of Elastic and Overstretching Properties of DNA:RNA Hybrid Duplexes.Biophysical journal · 2020Article
- Dynamic topology of double-stranded telomeric DNA studied by single-molecule manipulation in vitro.Nucleic acids research · 2020Article
- A Tour de Force on the Double Helix: Exploiting DNA Mechanics To Study DNA-Based Molecular Machines.Biochemistry · 2019Review
- Nanomechanics of Diaminopurine-Substituted DNA.Biophysical journal · 2019Article
- The Mechanical Properties of RNA-DNA Hybrid Duplex Stretched by Magnetic Tweezers.Biophysical journal · 2019Article
- A Horizontal Magnetic Tweezers and Its Use for Studying Single DNA Molecules.Micromachines · 2018Article
- Hyperstretching DNA.Nature communications · 2017Article
- Parallel triplex structure formed between stretched single-stranded DNA and homologous duplex DNA.Nucleic acids research · 2017Article
- Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers.Journal of visualized experiments : JoVE · 2017Article
- Oncofetal HMGA2 effectively curbs unconstrained (+) and (-) DNA supercoiling.Scientific reports · 2017Article
- Theoretical Methods for Studying DNA Structural Transitions under Applied Mechanical Constraints.Polymers · 2017Review
- Single-molecule studies of high-mobility group B architectural DNA bending proteins.Biophysical reviews · 2017Review
- An AT-barrier mechanically controls DNA reannealing under tension.Nucleic acids research · 2016Article
- Unravelling the structural plasticity of stretched DNA under torsional constraint.Nature communications · 2016Article
- Transcriptional Repressor TrmBL2 from Thermococcus kodakarensis Forms Filamentous Nucleoprotein Structures and Competes with Histones for DNA Binding in a Salt- and DNA Supercoiling-dependent Manner.The Journal of biological chemistry · 2015Article
- DNA under Force: Mechanics, Electrostatics, and Hydration.Nanomaterials (Basel, Switzerland) · 2015Review
- Mechanical force antagonizes the inhibitory effects of RecX on RecA filament formation in Mycobacterium tuberculosis.Nucleic acids research · 2014Article
- The transition mechanism of DNA overstretching: a microscopic view using molecular dynamics.Journal of the Royal Society, Interface · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The DNA double helix undergoes an 'overstretching' transition in a narrow force range near 65 pN. Despite numerous studies the basic question of whether the strands are separated or not remains controversial. Here we show that overstretching in fact involves two distinct types of double-helix reorganization: slow hysteretic 'unpeeling' of one strand off the other; and a fast, non-hysteretic transition to an elongated double-stranded form. We demonstrate that the relative fraction of these two overstretched forms is sensitive to factors that affect DNA base pair stability, including DNA sequence, salt concentration and temperature. The balance between the two forms shifts near physiological solution conditions. This result, in addition to establishing the existence of an overstretched double-stranded state, also shows that double helix physical properties are tuned so that either unpeeling or overextension can be selected via small changes in molecule environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.