Trial reportChest2010
The association between BMI and plasma cytokine levels in patients with acute lung injury.
Trial report in Chest, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
93 citing papers in PubMed, 3 syntheses or guidelines pooled it, 170 citations in OpenAlex.
- Obesity as a Risk Factor for Failure to Wean from ECMO: A Systematic Review and Meta-Analysis.Canadian respiratory journal · 2021Pooled it
- Pooled it
- Can body mass index predict clinical outcomes for patients with acute lung injury/acute respiratory distress syndrome? A meta-analysis.Critical care (London, England) · 2017Pooled it
- Body mass index and baricitinib treatment effect in hospitalized adults with COVID-19: A secondary analysis of ACTT-2.Heart & lung : the journal of critical careTrial
- The Association Between Body Mass Index and Acute Postoperative Pain in Bariatric Surgery Patients: A Prospective Cohort Study.Pain and therapy · 2026Article
- Triglyceride-Glucose Index Modifies Mortality Risk Across Body Mass Index Strata in Critically Ill Patients: A Retrospective Cohort Analysis of the MIMIC-IV Database.Journal of clinical medicine · 2026Article
- The impact of metabolic syndrome on regional ventilation and perfusion in ARDS: an observational cohort study using electrical impedance tomography.Intensive care medicine experimental · 2026Article
- Impact of obesity on outcomes of patients with acute respiratory distress syndrome: a retrospective analysis of a large clinical database.Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2024Article
- The association between nutritional status measured by body mass index and outcomes in the pediatric intensive care unit.Frontiers in pediatrics · 2024Article
- Body mass index is associated with pulmonary gas and blood distribution mismatch in COVID-19 acute respiratory failure. A physiological study.Frontiers in physiology · 2024Article
- A scoring model based on clinical factors to predict postoperative moderate to severe acute respiratory distress syndrome in Stanford type A aortic dissection.BMC pulmonary medicine · 2023Article
- Bioaerosol-induced in vitro activation of toll-like receptors and inflammatory biomarker expression in waste workers.International archives of occupational and environmental health · 2023Article
- Deletion of thePulmonary circulation · 2023Article
- Impact of Obesity on Clinical Outcomes of Patients with Intra-Abdominal Hypertension and Abdominal Compartment Syndrome.Life (Basel, Switzerland) · 2023Review
- Obesity Paradox in Lung Diseases: What Explains It?Obesity facts · 2023Review
- Clinical characteristics and outcome of Covid-19 illness and predictors of in-hospital mortality in Saudi Arabia.BMC infectious diseases · 2022Article
- The associations between body composition and vital capacity index of medical students in Shenyang of China: a cross-sectional survey.BMC pulmonary medicine · 2022Article
- Obesity Impact on SARS-CoV-2 Infection: Pros and Cons "Obesity Paradox"-A Systematic Review.Journal of clinical medicine · 2022Review
- Evaluating Possible Mechanisms Linking Obesity to COVID-19: a Narrative Review.Obesity surgery · 2022Review
- Obesity attenuates inflammation, protein catabolism, dyslipidaemia, and muscle weakness during sepsis, independent of leptin.Journal of cachexia, sarcopenia and muscle · 2022Article
33 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundObesity is associated with poor outcomes in many diseases, although recent data suggest that acute lung injury (ALI) is an exception. This is particularly interesting because obesity is marked by increased levels of proinflammatory mediators associated with increased morbidity and mortality in ALI. We hypothesized that cytokine response might be attenuated in patients who are obese and critically ill or that obesity might modify the relationship between plasma cytokines and clinical outcomes in ALI.
methodsWe analyzed plasma biomarker levels (interleukin [IL]-6, IL-8, tumor necrosis factor-alpha receptor 1, surfactant protein D [SP-D], soluble intracellular adhesion molecule, von Willebrand factor (vWF), protein C, and plasminogen activator inhibitor-1) collected at baseline and day 3 in 1,409 participants in prior National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Network (ARDSNet) trials. BMI was calculated for each patient, and associations with cytokine levels and ventilator-free days (VFDs), organ failure-free days (OFDs), and mortality were investigated in regression models adjusting for confounders.
resultsIn adjusted analyses, plasma IL-6 (P = .052), IL-8 (P = .001), and SP-D (P < .001) were inversely related to BMI, whereas vWF (P = .001) and WBC count (P = .042) increased proportionally with BMI. BMI was not associated with increased morbidity or mortality and did not modify the association between baseline biomarker levels and mortality, VFDs, or OFDs.
conclusionsPatients who are obese and have ALI have lower levels of several proinflammatory cytokines, suggesting that the inflammatory response may be altered in patients with ALI and a high BMI. Lower SP-D but higher vWF suggests decreased epithelial and increased endothelial injury in the lung of patients who are obese. Mechanisms by which obesity may modulate innate immunity in critical illness are unclear, and future studies should elucidate such mechanisms.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.