ArticleInvestigative ophthalmology & visual science2010
Ocular hemorrhages in neonatal porcine eyes from single, rapid rotational events.
Article in Investigative ophthalmology & visual science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Modeling of inflicted head injury by shaking trauma in children: what can we learn? : Part I: A systematic review of animal models.Forensic science, medicine, and pathology · 2019Pooled it
- Assessing Motion Fidelity During Closed-Head Rotational Acceleration Traumatic Brain Injury in Pigs.Research square · 2026Article
- New Insights into the Diagnosis and Age Determination of Retinal Hemorrhages from Abusive Head Trauma: A Systematic Review.Diagnostics (Basel, Switzerland) · 2023Review
- Abusive Head Trauma Animal Models: Focus on Biomarkers.International journal of molecular sciences · 2023Review
- Article
- Animal models of pediatric abusive head trauma.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022Review
- Reproducibility and Characterization of Head Kinematics During a Large Animal Acceleration Model of Traumatic Brain Injury.Frontiers in neurology · 2021Article
- Modeling Hypertension as a Contributor to Retinal Hemorrhaging from Abusive Head Trauma.Journal of healthcare engineering · 2020Article
- Cyclic Head Rotations Produce Modest Brain Injury in Infant Piglets.Journal of neurotrauma · 2017Article
- A Porcine Model of Traumatic Brain Injury via Head Rotational Acceleration.Methods in molecular biology (Clifton, N.J.) · 2016Article
- The eye in child abuse: key points on retinal hemorrhages and abusive head trauma.Pediatric radiology · 2014Review
- Patterns of retinal hemorrhage associated with increased intracranial pressure in children.Pediatrics · 2013Article
- Negative g-Force Ocular Trauma Caused by a Rapidly Spinning Carousel.Case reports in ophthalmology · 2013Article
- Educational paper : retinal haemorrhages in abusive head trauma in children.European journal of pediatrics · 2012Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeTo characterize ocular hemorrhages from single, rapid head rotations in the neonatal pig.
methodsThree- to 5-day-old anesthetized piglets (n=51) underwent a single, rapid (117-266 rad/s) head rotation in the sagittal (n=13), coronal (n=7), or axial (n=31) planes. Six hours after injury, the animals were euthanatized and perfusion fixed, and the brain and eyes were harvested for gross and histopathologic examination by masked neuro- and ocular pathologists.
resultsOcular hemorrhage was found in 73% of animals (51% bilateral). Intraocular hemorrhage was primarily located near the vitreous base (70% of injured animals had ciliary body hemorrhage, and 11% had peripheral retinal hemorrhage). Hemorrhages were also found in the anterior chamber (11%), vitreous (5%), and optic nerve (disc, 8%; nerve sheath, 57%). Rapid axial head rotations resulted in a higher incidence of intraocular hemorrhage than coronal or sagittal head rotations, but the difference did not reach statistical significance (P=0.06). Control eyes had no injuries.
conclusionsOptic nerve sheath and ciliary body hemorrhages were common in piglets that experienced a single, rapid head rotation. Retinal hemorrhage was present in a smaller number of animals. Most intraocular hemorrhages were located in regions of strong vitreous attachment, suggesting that this animal model will be useful in investigating the effect of vitreoretinal adhesion on ocular hemorrhage caused by inertial head rotations. Extrapolation of this model to the human infant should not be made until the effect of anatomic differences between the human and pig on the occurrence and patterns of ocular injuries is further investigated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.