ArticleEnvironmental health perspectives2010
Plasma organochlorines and subsequent risk of prostate cancer in Japanese men: a nested case-control study.
Article in Environmental health perspectives, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Body concentrations of persistent organic pollutants and prostate cancer: a meta-analysis.Environmental science and pollution research international · 2015Pooled it
- Farming, reported pesticide use, and prostate cancer.American journal of men's health · 2013Pooled it
- Lipid‑disrupting effects of an organochlorine mixture in Sertoli TM4 cells reveal testicular obesogen mechanisms.Archives of toxicology · 2026Article
- Exposure to environmental chemicals and cancer risk: epidemiological evidence from Japanese studies.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2023Review
- Differential Bioaccumulation Patterns of α, β-Hexachlorobenzene and Dicofol in Adipose Tissue from the GraMo Cohort (Southern Spain).International journal of environmental research and public health · 2022Article
- Breast and prostate glands affected by environmental substances (Review).Oncology reports · 2021Review
- Occupational Risk Factors for Prostate Cancer: A Meta-analysis.Journal of cancer prevention · 2019Review
- Cancer incidence among capacitor manufacturing workers exposed to polychlorinated biphenyls.American journal of industrial medicine · 2017Article
- Risk and preventive factors for prostate cancer in Japan: The Japan Public Health Center-based prospective (JPHC) study.Journal of epidemiology · 2017Article
- EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals.Endocrine reviews · 2015Review
- Prediagnostic Serum Organochlorine Concentrations and Metastatic Prostate Cancer: A Nested Case-Control Study in the Norwegian Janus Serum Bank Cohort.Environmental health perspectives · 2015Article
- Associations of plasma concentrations of dichlorodiphenyldichloroethylene and polychlorinated biphenyls with prostate cancer: a case-control study in Guadeloupe (French West Indies).Environmental health perspectives · 2015Article
- Evaluation of pesticide residues in human blood samples from Punjab (India).Veterinary world · 2015Article
- Organochlorine pesticide residue levels in blood serum of inhabitants from Veracruz, Mexico.Environmental monitoring and assessment · 2012Article
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Authors and funding
9 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough accumulating evidence suggests that exposure to organochlorine pesticides and polychlorinated biphenyls (PCBs) may contribute to the development of prostate cancer, few investigations have used biological samples to classify exposure to specific organochlorines. To our knowledge, this is the first prospective study to investigate the association between blood levels of organochlorines and prostate cancer risk.
methodsWe conducted a nested case-control study using data from the Japan Public Health Center-based Prospective (JPHC) Study. A total of 14,203 men 40-69 years old who returned the baseline questionnaire and who provided blood samples were followed from 1990 to 2005. Using a mean follow-up period of 12.8 years, we identified 201 participants who were newly diagnosed with prostate cancer. Two matched controls for each case were selected from the cohort. We used a conditional logistic regression model to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) for prostate cancer in relation to plasma levels of nine organochlorines: PCBs, dichlorodiphenyltrichloroethane (DDT), hexachlorobenzene (HCB), beta-hexachlorocyclohexane (beta-HCH), trans- and cis-nonachlor, oxychlordane, and mirex.
resultsNo statistically significant association with total prostate cancer was seen for any plasma organochlorine, although we did observe an insignificant inverse association for plasma HCB and beta-HCH. Total PCB in plasma was also inversely associated with advanced prostate cancer but without statistical significance.
conclusionOur results suggest that no overall association exists between prostate cancer and organochlorines at the levels measured in our study population.
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