ArticleEnvironmental health perspectives2010
Maternal dioxin exposure combined with a diet high in fat increases mammary cancer incidence in mice.
Article in Environmental health perspectives, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 42 citations in OpenAlex.
- Dioxins do not only bind to AHR but also team up with EGFR at the cell-surface: a novel mode of action of toxicological relevance?EXCLI journal · 2025Review
- Chronic Exposure to Low Levels of Parabens Increases Mammary Cancer Growth and Metastasis in Mice.Endocrinology · 2023Article
- Environmental exposure and the role of AhR in the tumor microenvironment of breast cancer.Frontiers in pharmacology · 2022Review
- Maternal obesity and the impact of associated early-life inflammation on long-term health of offspring.Frontiers in cellular and infection microbiology · 2022Review
- Using the Key Characteristics of Carcinogens to Develop Research on Chemical Mixtures and Cancer.Environmental health perspectives · 2021Article
- Endocrine-disrupting chemicals and breastfeeding duration: a review.Current opinion in endocrinology, diabetes, and obesity · 2020Review
- Maternal obesogenic diet induces endometrial hyperplasia, an early hallmark of endometrial cancer, in a diethylstilbestrol mouse model.PloS one · 2018Article
- Dioxin and the AH Receptor: Synergy of Discovery.Current opinion in toxicology · 2017Article
- Dietary exposure to polychlorinated biphenyls and risk of breast, endometrial and ovarian cancer in a prospective cohort.British journal of cancer · 2016Article
- 2,3,7,8-Tetrachlorodibenzo-p-dioxin has both pro-carcinogenic and anti-carcinogenic effects on neuroendocrine prostate carcinoma formation in TRAMP mice.Toxicology and applied pharmacology · 2016Article
- Maternal Obesity, Cage Density, and Age Contribute to Prostate Hyperplasia in Mice.Reproductive sciences (Thousand Oaks, Calif.) · 2016Article
- Effects of obesity on hormonally driven cancer in women.Science translational medicine · 2016Review
- Timing of Environmental Exposures as a Critical Element in Breast Cancer Risk.The Journal of clinical endocrinology and metabolism · 2015Review
- DDT Exposure in Utero and Breast Cancer.The Journal of clinical endocrinology and metabolism · 2015Article
- Multiscale analysis of the murine intestine for modeling human diseases.Integrative biology : quantitative biosciences from nano to macro · 2015Article
- Advancing research on endocrine disrupting chemicals in breast cancer: Expert panel recommendations.Reproductive toxicology (Elmsford, N.Y.) · 2015Review
- Maternal high-fat diet induces hyperproliferation and alters Pten/Akt signaling in prostates of offspring.Scientific reports · 2013Article
- TCDD inhibition of canonical Wnt signaling disrupts prostatic bud formation in mouse urogenital sinus.Toxicological sciences : an official journal of the Society of Toxicology · 2013Article
- Genetic polymorphisms in CYP1A1, CYP1B1 and COMT genes in Greenlandic Inuit and Europeans.International journal of circumpolar health · 2013Article
- Action of Halowax 1051 on Enzymes of Phase I (CYP1A1) and Phase II (SULT1A and COMT) Metabolism in the Pig Ovary.International journal of endocrinology · 2013Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundRESULTS from previous studies have suggested that breast cancer risk correlates with total lifetime exposure to estrogens and that early-life 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure or diets high in fat can also increase cancer risk.
objectivesBecause both TCDD and diet affect the estrogen pathway, we examined how TCDD and a high-fat diet (HFD) interact to alter breast cancer susceptibility.
methodsWe exposed pregnant female FVB/NJ mice (12.5 days postcoitus) to 1 microg/kg TCDD or vehicle; at parturition, the dams were randomly assigned to a low-fat diet (LFD) or a high-fat diet (HFD). Female offspring were maintained on the same diets after weaning and were exposed to 7,12-dimethylbenz[a]anthracene on postnatal days (PNDs) 35, 49, and 63 to initiate mammary tumors. A second cohort of females was treated identically until PND35 or PND49, when mammary gland morphology was examined, or PND50, when mammary gland mRNA was analyzed.
resultsWe found that maternal TCDD exposure doubled mammary tumor incidence only in mice fed the HFD. Among HFD-fed mice, maternal TCDD exposure caused rapid mammary development with increased Cyp1b1 (cytochrome P450 1B1) expression and decreased Comt (catechol-O-methyltransferase) expression in mammary tissue. Maternal TCDD exposure also increased mammary tumor Cyp1b1 expression.
conclusionsOur data suggest that the HFD increases sensitivity to maternal TCDD exposure, resulting in increased breast cancer incidence, by changing metabolism capability. These results provide a mechanism to explain epidemiological data linking early-life TCDD exposure and diets high in fat to increased risk for breast cancer in humans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.