Evidence map›Paper›PMID 20435544›Full record

ArticleEnvironmental health perspectives2010

Triggering of transmural infarctions, but not nontransmural infarctions, by ambient fine particles.

David Q Rich, Howard M Kipen, Junfeng Zhang, Leena Kamat, Alan C Wilson, John B Kostis

Registry-linked trialOpen access · diamondAbstract read
In one paragraph

Article in Environmental health perspectives, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05731830 (Takotsubo Syndrome and Air Pollution), which is not on this map. Cited by 29 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 3 pooled it
2.6field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05731830 recruitingnot on this mapstarted 2022, after this paper: background citation

Takotsubo Syndrome and Air Pollution: the "Tako-Air" Study

TypeobservationalSponsorFondazione Policlinico Universitario Agostino Gemelli IRCCSRan2022 to 2026Enrolled250ConditionsTakotsubo SyndromeArmsData extraction, Clinical follow-up
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Association between PMBMC public health · 2020
    Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Long-Term Exposure to Ambient PMJournal of the American Heart Association · 2023
    Article
  7. Clustering of Environmental Parameters and the Risk of Acute Myocardial Infarction.International journal of environmental research and public health · 2022
    Article
  8. Effect modification by sex for associations of fine particulate matter (PMEnvironmental research letters : ERL [Web site] · 2022
    Article
  9. Ambient PMNature communications · 2018
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Ambient Particulate Matter (PMJournal of epidemiology · 2016
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

David Q RichSchool of Public Health, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey, USA. David_Rich@URMC.Rochester.edu
Howard M Kipen
Junfeng Zhang
Leena Kamat
Alan C Wilson
John B Kostis
Rutgers, The State University of New Jersey · US

Funding

Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI Emily S Barrett · 1988 to 2026
$47.4M
NIEHS NIH HHS P30 ES005022NIEHS NIH HHS P30ES005022
6 · The paper itself

Abstract

backgroundPrevious studies have reported increased risk of myocardial infarction (MI) after increases in ambient particulate matter (PM) air pollution concentrations in the hours and days before MI onset.

objectivesWe hypothesized that acute increases in fine PM with aerodynamic diameter < or = 2.5 microm (PM(2.5)) may be associated with increased risk of MI and that chronic obstructive pulmonary disease (COPD) and diabetes may increase susceptibility to PM(2.5). We also explored whether both transmural and nontransmural infarctions were acutely associated with ambient PM(2.5) concentrations.

methodsWe studied all hospital admissions from 2004 through 2006 for first acute MI of adult residents of New Jersey who lived within 10 km of a PM(2.5) monitoring site (n = 5,864), as well as ambient measurements of PM(2.5), nitrogen dioxide, sulfur dioxide, carbon monoxide, and ozone.

resultsUsing a time-stratified case-crossover design and conditional logistic regression showed that each interquartile-range increase in PM(2.5) concentration (10.8 microg/m3) in the 24 hr before arriving at the emergency department for MI was not associated with MI overall but was associated with an increased relative risk of a transmural infarction. We found no association between the same increase in PM(2.5) and nontransmural infarction. Further, subjects with COPD appeared to be particularly susceptible, but those with diabetes were not.

conclusionsThis PM-transmural infarction association is consistent with earlier studies of PM and MI. The lack of association with nontransmural infarction suggests that future studies that investigate the triggering of MI by ambient PM(2.5) concentrations should be stratified by infarction type.

Indexed as

AdultAgedAged, 80 and overFemaleHumansLogistic ModelsMaleMiddle AgedMyocardial InfarctionParticulate MatterWeatherYoung AdultParticulate Matter

Identifiers

PMID20435544
PMCPMC2944082
OpenAlexW2017509095

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.