ArticleSchizophrenia research2010
Consanguinity and increased risk for schizophrenia in Egypt.
Article in Schizophrenia research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 58 citations in OpenAlex.
- Preliminary studies on apparent mendelian psychotic disorders in consanguineous families.BMC psychiatry · 2022Article
- Morbidity and mortality of COVID-19 negatively associated with the frequency of consanguineous marriages, an ecologic study.The Egyptian journal of medical human genetics · 2022Article
- Descriptive study of cases of schizophrenia in the Malian population.BMC psychiatry · 2021Article
- A Recessively Inherited Risk Locus on Chromosome 13q22-31 Conferring Susceptibility to Schizophrenia.Schizophrenia bulletin · 2021Article
- Age dependent association of inbreeding with risk for schizophrenia in Egypt.Schizophrenia research · 2020Article
- Runs of homozygosity, copy number variation, and risk for depression and suicidal behavior in an Arab Bedouin kindred.Psychiatric genetics · 2017Article
- No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study.PLoS genetics · 2016Article
- Article
- Analysis of exome sequence in 604 trios for recessive genotypes in schizophrenia.Translational psychiatry · 2015Article
- Characterizing runs of homozygosity and their impact on risk for psychosis in a population isolate.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2014Article
- The association of genotype-based inbreeding coefficient with a range of physical and psychological human traits.PloS one · 2014Article
- Does consanguinity increase the risk of schizophrenia? Study based on primary health care centre visits.Mental health in family medicine · 2012Article
- Runs of homozygosity implicate autozygosity as a schizophrenia risk factor.PLoS genetics · 2012Article
- The emergence of human-evolutionary medical genomics.Evolutionary applications · 2011Article
- Identification of novel schizophrenia loci by homozygosity mapping using DNA microarray analysis.PloS one · 2011Article
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Authors and funding
22 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundConsanguinity has been suggested as a risk factor for psychoses in some Middle Eastern countries, but adequate control data are unavailable. Our recent studies in Egypt have shown elevated parental consanguinity rates among patients with bipolar I disorder (BP1), compared with controls. We have now extended our analyses to schizophrenia (SZ) in the same population.
methodsA case-control study was conducted at Mansoura University Hospital, Mansoura, Egypt (SZ, n=75; controls, n=126, and their available parents). The prevalence of consanguinity was estimated from family history data ('self report'), followed by DNA analysis using short tandem repeat polymorphisms (STRPs, n=63) ('DNA-based' rates).
resultsSelf-reported consanguinity was significantly elevated among the patients (SZ: 46.6%, controls: 19.8%, OR 3.53, 95% CI 1.88, 6.64; p=0.000058, 1 d.f.). These differences were confirmed using DNA-based estimates for coefficients of inbreeding (inbreeding coefficients as means+/-standard error, cases: 0.058+/-0.007, controls: 0.022+/-0.003).
conclusionsConsanguinity rates are significantly elevated among Egyptian SZ patients in the Nile delta region. The associations are similar to those observed with BP1 in our earlier study. If replicated, the substantial risk associated with consanguinity raises public health concerns. They may also pave the way for gene mapping studies.
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