ReviewBiochimica et biophysica acta2011
Nanoscale engineering of extracellular matrix-mimetic bioadhesive surfaces and implants for tissue engineering.
Review in Biochimica et biophysica acta, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
- Regenerative Nano-scaffolds for Tissue Engineering: From Bench to Clinical Translation.Biomaterials research · 2026Article
- Lateral Spacing of TiOBiomimetics (Basel, Switzerland) · 2025Article
- Collagen type I mimicking peptide additives to functionalize synthetic supramolecular hydrogels.Materials today. Bio · 2024Article
- Carbon Quantum Dots for Stem Cell Imaging and Deciding the Fate of Stem Cell Differentiation.ACS omega · 2022Review
- Engineering of Bio-Adhesive Ligand Containing Recombinant RGD and PHSRN Fibronectin Cell-Binding Domains in Fusion with a Colored Multi Affinity Tag: Simple Approach for Fragment Study from Expression to Adsorption.International journal of molecular sciences · 2021Article
- Graphene-Based Scaffolds for Regenerative Medicine.Nanomaterials (Basel, Switzerland) · 2021Review
- Non-thermal plasma assisted surface nano-textured carboxymethyl guar gum/chitosan hydrogels for biomedical applications.RSC advances · 2019Article
- The Effect of Fibronectin-Immobilized Microgrooved Titanium Substrata on Cell Proliferation and Expression of Genes and Proteins in Human Gingival Fibroblasts.Tissue engineering and regenerative medicine · 2018Article
- Enhanced Biocompatibility in Anodic TaONanoscale research letters · 2017Article
- Paediatric nanofibrous bioprosthetic heart valve.IET nanobiotechnology · 2017Review
- Electrokinetic Properties of TiO2 Nanotubular Surfaces.Nanoscale research letters · 2016Article
- Capillary Electrophoresis to Monitor Peptide Grafting onto Chitosan Films in Real Time.Journal of visualized experiments : JoVE · 2016Article
- Challenges and Opportunities to Harnessing the (Hematopoietic) Stem Cell Niche.Current stem cell reports · 2016Article
- Nanoscale Surface Modifications of Medical Implants for Cartilage Tissue Repair and Regeneration.The open orthopaedics journal · 2016Article
- Biomimetic substrate control of cellular mechanotransduction.Biomaterials research · 2016Review
- A Review of Current Regenerative Medicine Strategies that Utilize Nanotechnology to Treat Cartilage Damage.The open orthopaedics journal · 2016Article
- Research trends in biomimetic medical materials for tissue engineering: commentary.Biomaterials research · 2016Article
- Nano- and microstructured materials for in vitro studies of the physiology of vascular cells.Beilstein journal of nanotechnology · 2016Review
- Nanotechnology and bio-functionalisation for peripheral nerve regeneration.Neural regeneration research · 2015Review
- Development of a biological scaffold engineered using the extracellular matrix secreted by skeletal muscle cells.Biomaterials · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
backgroundThe goal of tissue engineering is to restore tissue function using biomimetic scaffolds which direct desired cell fates such as attachment, proliferation and differentiation. Cell behavior in vivo is determined by a complex interaction of cells with extracellular biosignals, many of which exist on a nanoscale. Therefore, recent efforts in tissue engineering biomaterial development have focused on incorporating extracellular matrix- (ECM) derived peptides or proteins into biomaterials in order to mimic natural ECM. Concurrent advances in nanotechnology have also made it possible to manipulate protein and peptide presentation on surfaces on a nanoscale level. SCOPE OF REVIEW: This review discusses protein and peptide nanopatterning techniques and examples of how nanoscale engineering of bioadhesive materials may enhance outcomes for regenerative medicine. MAJOR
conclusionsSynergy between ECM-mimetic tissue engineering and nanotechnology fields can be found in three major strategies: (1) Mimicking nanoscale orientation of ECM peptide domains to maintain native bioactivity, (2) Presenting adhesive peptides at unnaturally high densities, and (3) Engineering multivalent ECM-derived peptide constructs. GENERAL SIGNIFICANCE: Combining bioadhesion and nanopatterning technologies to allow nanoscale control of adhesive motifs on the cell-material interface may result in exciting advances in tissue engineering. This article is part of a Special Issue entitled Nanotechnologies - Emerging Applications in Biomedicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.