ArticleNeuron2010
The androgen receptor governs the execution, but not programming, of male sexual and territorial behaviors.
Article in Neuron, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers.
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Who cites it
116 citing papers in PubMed, 259 citations in OpenAlex.
- Dysregulation of neuronal androgen receptor signaling by divergent collaborative transcription factors in Alzheimer's disease.iScience · 2026Article
- Differential Effects of 3.5 GHz and 24 GHz 5G Radiofrequency Exposure on Male Sexual Behaviour and Reproductive Endocrine Function in Rats.International journal of molecular sciences · 2026Article
- Article
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- Context rescales a social action code in a hormone-sensitive network.bioRxiv : the preprint server for biology · 2025Article
- Estrogen Control of Social Behaviors.Annual review of neuroscience · 2025Review
- Long-term systemic androgen deprivation partially modulates neuroinflammation in male AppScientific reports · 2025Article
- Review
- Sexually dimorphic control of aggression by androgen signaling in a cichlid.Molecular and cellular endocrinology · 2024Article
- Androgen regulation of behavioral stress responses and the hypothalamic-pituitary-adrenal axis.Hormones and behavior · 2024Review
- The decision of male medaka to mate or fight depends on two complementary androgen signaling pathways.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Sexually dimorphic control of aggression by androgen signaling in a cichlid.bioRxiv : the preprint server for biology · 2024Article
- Comparative analysis of gonadal hormone receptor expression in the postnatal house mouse, meadow vole, and prairie vole brain.Hormones and behavior · 2024Article
- Sex and interspecies differences in ESR2-expressing cell distributions in mouse and rat brains.Biology of sex differences · 2023Article
- Article
- Zebrafish gonad mutant models reveal neuroendocrine mechanisms of brain sexual dimorphism and male mating behaviors of different brain regions.Biology of sex differences · 2023Article
- Hypothalamic neurons that mirror aggression.Cell · 2023Article
- Evolutionary differentiation of androgen receptor is responsible for sexual characteristic development in a teleost fish.Nature communications · 2023Article
- The elusive concept of sexual motivation: can it be anchored in the nervous system?Frontiers in neuroscience · 2023Review
- Genetic dissection of steroid-hormone modulated social behavior: Novel paralogous genes are a boon for discovery.Hormones and behavior · 2023Review
56 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Testosterone and estrogen are essential for male behaviors in vertebrates. How these two signaling pathways interact to control masculinization of the brain and behavior remains to be established. Circulating testosterone activates the androgen receptor (AR) and also serves as the source of estrogen in the brain. We have used a genetic strategy to delete AR specifically in the mouse nervous system. This approach permits us to determine the function of AR in sexually dimorphic behaviors in males while maintaining circulating testosterone levels within the normal range. We find that AR mutant males exhibit masculine sexual and territorial displays, but they have striking deficits in specific components of these behaviors. Taken together with the surprisingly limited expression of AR in the developing brain, our findings indicate that testosterone acts as a precursor to estrogen to masculinize the brain and behavior, and signals via AR to control the levels of male behavioral displays.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.