ArticleNeuropeptides2010
Alarin stimulates food intake in male rats and LH secretion in castrated male rats.
Article in Neuropeptides, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Trial
- Alarin as a potential biomarker in childhood obesity: Evidence from a case-control study.Medicine · 2026Article
- Comparison of cord blood alarin levels of full-term infants according to birth weight.Journal of perinatal medicine · 2025Article
- Transportation Stress Increases Fos Immunoreactivity in the Paraventricular Nucleus, but Not in the Nucleus of the Hippocampal Commissure in the Pekin Duck,Animals : an open access journal from MDPI · 2022Article
- Androgenetic Alopecia and Metabolic Syndrome: Is Alarin a Missing Link?The Journal of clinical and aesthetic dermatology · 2022Article
- Serum Tenascin-C and Alarin Levels Are Associated with Cardiovascular Diseases in Type 2 Diabetes Mellitus.International journal of endocrinology · 2022Article
- Regulatory effects and potential therapeutic implications of alarin in depression, and arguments on its receptor.Frontiers in psychiatry · 2022Review
- Galanin family peptides: Molecular structure, expression and roles in the neuroendocrine axis and in the spinal cord.Frontiers in endocrinology · 2022Review
- The evolving roles of alarin in physiological and disease conditions, and its future potential clinical implications.Frontiers in endocrinology · 2022Review
- Neuropeptidergic Control of Feeding: Focus on the Galanin Family of Peptides.International journal of molecular sciences · 2021Review
- Plasma Alarin Level and Its Influencing Factors in Obese Newly Diagnosed Type 2 Diabetes Patients.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- [Level of circulating Alarin in obese children and its association with insulin resistance].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2019Article
- Expression of alarin in ependymoma and choroid plexus tumors.Journal of neuro-oncology · 2013Article
- Evolution of a potential hormone antagonist following gene splicing during primate evolution.PloS one · 2013Article
- Distribution of alarin immunoreactivity in the mouse brain.Journal of molecular neuroscience : MN · 2012Article
- Galanin receptors and ligands.Frontiers in endocrinology · 2012Article
- Sense and nonsense in metabolic control of reproduction.Frontiers in endocrinology · 2012Article
- Beyond Leptin: Emerging Candidates for the Integration of Metabolic and Reproductive Function during Negative Energy Balance.Frontiers in endocrinology · 2011Article
- Thermoregulatory effect of alarin, a new member of the galanin peptide family.Temperature (Austin, Tex.)Article
- ASSESSMENT OF SERUM ALARIN LEVELS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS.Acta endocrinologica (Bucharest, Romania : 2005)Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Alarin is a newly identified member of the galanin family of neuropeptides that includes galanin-like peptide (GALP) and galanin. Alarin was discovered as an alternate transcript of the GALP gene in neuroblastoma cells, and subsequently alarin mRNA was detected in the brain of rodents. GALP and galanin are important central regulators of both feeding and reproductive behavior. We hypothesized, that, as a member of the galanin family of peptides, alarin would also have central effects on feeding and reproduction. To test this hypothesis, we treated male rats with alarin intracerebroventricularly (i.c.v.) and measured its effects on food intake and energy homeostasis as well as sexual behavior and luteinizing hormone (LH) secretion. We observed that i.c.v. injection of 1.0 nmol alarin significantly increased food intake (p<0.01) and body weight (p<0.05). Alarin did not affect sexual behavior in male rats; however, alarin did significantly (p<0.01) increase LH levels in castrated, but not intact, male rats. Alarin immunoreactive cell bodies were detected within the locus coeruleus and locus subcoeruleus of the midbrain, which is a brainstem nucleus involved in coordinating many physiological activities, including food intake and reproduction. Lastly, alarin stimulated Fos induction in hypothalamic nuclei, such as the paraventricular nucleus and the nucleus of the tractus solitarious. Our studies demonstrate that alarin, like other members of the galanin family, is a neuromediator of food intake and body weight.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.