ArticleNeuroscience letters2010
Sex and hormonal variations in the development of at-level allodynia in a rat chronic spinal cord injury model.
Article in Neuroscience letters, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- The role of sex hormones in neurological and functional recovery following spinal cord injury in females: a systematic review of the literature.Spinal cord · 2026Pooled it
- Neuropathic Pain Induced by Spinal Cord Injury from the Glia Perspective and Its Treatment.Cellular and molecular neurobiology · 2024Review
- Noxious Stimulation Induces Acute Hemorrhage and Impairs Long-Term Recovery after Spinal Cord Injury (SCI) in Female Rats: Evidence Estrous Cycle May Have a Modulatory Effect.Neurotrauma reports · 2022Article
- Modelling at-level allodynia after mid-thoracic contusion in the rat.European journal of pain (London, England) · 2021Article
- Estrogen receptors in pain modulation: cellular signaling.Biology of sex differences · 2021Review
- Sex Differences in a Rat Model of Peripheral Neuropathic Pain and Associated Levels of Endogenous Cannabinoid Ligands.Frontiers in pain research (Lausanne, Switzerland) · 2021Article
- Effect of Sex on Motor Function, Lesion Size, and Neuropathic Pain after Contusion Spinal Cord Injury in Mice.Journal of neurotrauma · 2020Article
- Considerations for Studying Sex as a Biological Variable in Spinal Cord Injury.Frontiers in neurology · 2020Article
- Sexual Dimorphism of Pain Control: Analgesic Effects of Pioglitazone and Azithromycin in Chronic Spinal Cord Injury.Journal of neurotrauma · 2019Article
- Functional and Histological Gender Comparison of Age-Matched Rats after Moderate Thoracic Contusive Spinal Cord Injury.Journal of neurotrauma · 2019Article
- Estrogen Attenuates Local Inflammasome Expression and Activation after Spinal Cord Injury.Molecular neurobiology · 2018Article
- Hormonal therapy in traumatic spinal cord injury.American journal of translational research · 2017Review
- A model of acute central cervical spinal cord injury syndrome combined with chronic injury in goats.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2017Article
- Training-Induced Functional Gains following SCI.Neural plasticity · 2016Article
- Effects of estrogen on functional and neurological recovery after spinal cord injury: An experimental study with rats.Clinics (Sao Paulo, Brazil) · 2015Article
- Estradiol attenuates spinal cord injury-related central pain by decreasing glutamate levels in thalamic VPL nucleus in male rats.Metabolic brain disease · 2014Article
- Novel multi-system functional gains via task specific training in spinal cord injured male rats.Journal of neurotrauma · 2014Article
- Cell cycle activation contributes to increased neuronal activity in the posterior thalamic nucleus and associated chronic hyperesthesia after rat spinal cord contusion.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2013Article
- Modulation of temporomandibular joint nociception and inflammation in male rats after administering a physiological concentration of 17β-oestradiol.European journal of pain (London, England) · 2013Article
- Estradiol treatment prevents injury induced enhancement in spinal cord dynorphin expression.Frontiers in physiology · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The development of central neuropathic pain varies among patients with spinal cord injury (SCI). The factors contributing to the development and perpetuation of segmental pain (at-level allodynia) has been the focus of ongoing experiments in our laboratory. One such factor is hormonal status. We have shown previously, using a male rat model of SCI, that a severe contusion injury is necessary for the development of allodynia in trunk regions at and just above the level of a T8 injury. In this study, we examined at-level sensitivity for SCI ovariectomized (ovx) and cycling female rats as well as for SCI males implanted with either a placebo pellet or one that slowly releases 17beta-estradiol. The proportion of ovx SCI female rats and placebo-treated SCI males displaying pain-like behaviors to touch/pressure of at-level dermatomes up to 6 weeks post-injury (67% and 75%, respectively) was similar to our previous studies on SCI males (69%). In contrast, significantly fewer cycling SCI female rats and 17beta-estradiol treated SCI male rats showed sensitivity to touch at-level (26% and 30%, respectively). These results implicate 17beta-estradiol as a potential target that can readily be modulated to prevent segmental pain following SCI.
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Registered trials
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