ReviewFEBS letters2010
Examining the case for the effect of barrier compression on tunneling, vibrationally enhanced catalysis, catalytic entropy and related issues.
Review in FEBS letters, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 83 citations in OpenAlex.
- Impact of Structural Flexibility on Tunneling Contribution to the Reaction Mechanism of Spontaneous Succinimide Formation in Asn-Gly-Containing Peptides.Biomolecules · 2026Article
- How important are quantum mechanical effects in controlling biological functions: Enzymes, electron transfer and bird navigation.Protein science : a publication of the Protein Society · 2026Review
- Interplay of structural preorganization and conformational sampling in UDP-glucuronic acid 4-epimerase catalysis.Nature communications · 2024Article
- Adduct under Field-A Qualitative Approach to Account for Solvent Effect on Hydrogen Bonding.Molecules (Basel, Switzerland) · 2020Article
- Kinetic isotope effects and how to describe them.Structural dynamics (Melville, N.Y.) · 2017Review
- NMR and IR Investigations of Strong Intramolecular Hydrogen Bonds.Molecules (Basel, Switzerland) · 2017Review
- Perspective: Defining and quantifying the role of dynamics in enzyme catalysis.The Journal of chemical physics · 2016Review
- Enzymatic Kinetic Isotope Effects from First-Principles Path Sampling Calculations.Journal of chemical theory and computation · 2016Article
- The Use of Multiscale Molecular Simulations in Understanding a Relationship between the Structure and Function of Biological Systems of the Brain: The Application to Monoamine Oxidase Enzymes.Frontiers in neuroscience · 2016Review
- The Quantum Nature of Drug-Receptor Interactions: Deuteration Changes Binding Affinities for Histamine Receptor Ligands.PloS one · 2016Article
- Does the pressure dependence of kinetic isotope effects report usefully on dynamics in enzyme H-transfer reactions?The FEBS journal · 2015Review
- The entropic contributions in vitamin B12 enzymes still reflect the electrostatic paradigm.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Methyltransferases do not work by compression, cratic, or desolvation effects, but by electrostatic preorganization.Proteins · 2015Article
- Modeling catalytic promiscuity in the alkaline phosphatase superfamily.Physical chemistry chemical physics : PCCP · 2013Article
- Computational protein engineering: bridging the gap between rational design and laboratory evolution.International journal of molecular sciences · 2012Review
- Gauging the flexibility of the active site in soybean lipoxygenase-1 (SLO-1) through an atom-centered density matrix propagation (ADMP) treatment that facilitates the sampling of rare events.The journal of physical chemistry. B · 2012Article
- Hydrogen donor-acceptor fluctuations from kinetic isotope effects: a phenomenological model.Biochemistry · 2012Article
- Good vibrations in enzyme-catalysed reactions.Nature chemistry · 2012Article
- Effects of the donor-acceptor distance and dynamics on hydride tunneling in the dihydrofolate reductase catalyzed reaction.Journal of the American Chemical Society · 2012Article
- The role of large-scale motions in catalysis by dihydrofolate reductase.Journal of the American Chemical Society · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The idea that tunneling is enhanced by the compression of the donor-acceptor distance has attracted significant interest. In particular, recent studies argued that this proposal is consistent with pressure effects on enzymatic reactions, and that the observed pressure effects support the idea of vibrationally enhanced catalysis. However, a careful analysis of the current works reveals serious inconsistencies in the evidence presented to support these hypotheses. Apparently, tunneling decreases upon compression, and external pressure does not lead to the applicable compression of the free energy surface. Additionally, pressure experiments do not provide actual evidence for vibrationally enhanced catalysis. Finally, the temperature dependence of the entropy change in hydride transfer reactions is shown to reflect simple electrostatic effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.