ArticleBMC medical genetics2010
PedHunter 2.0 and its usage to characterize the founder structure of the Old Order Amish of Lancaster County.
Article in BMC medical genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 49 citations in OpenAlex.
- The Pharmacogenomics of Anti-Platelet Intervention (PAPI) Study: Variation in Platelet Response to Clopidogrel and Aspirin.Current vascular pharmacology · 2016Trial
- The population structure of the Amish, a rapidly growing ethnic religion in North America.Population studies · 2026Article
- Genetics of Response to Canagliflozin (GRC) Study: Rationale, Design, and Pharmacodynamic Responses.Clinical and translational science · 2026Article
- Exonic Variation and Its Clinical Impact in 7221 Old Order Amish.American journal of medical genetics. Part A · 2025Article
- Attitudes toward returning pathogenicGenetics in medicine open · 2025Article
- Psychometric approaches to defining cognitive phenotypes in the Old Order Amish.International journal of geriatric psychiatry · 2023Article
- Article
- Ancestral haplotype reconstruction in endogamous populations using identity-by-descent.PLoS computational biology · 2021Article
- Research Trends in Amish Population Health, a Growing Literature about a Growing Rural Population.Journal of rural social sciences · 2021Article
- The Amish health culture and culturally sensitive health services: An exhaustive narrative review.Social science & medicine (1982) · 2020Review
- Article
- Sex-specific effects of serum sulfate level andMolecular genetics and metabolism reports · 2017Article
- From Genotype to Phenotype: Nonsense Variants in SLC13A1 Are Associated with Decreased Serum Sulfate and Increased Serum Aminotransferases.G3 (Bethesda, Md.) · 2016Article
- Cognitive profiles and heritability estimates in the Old Order Amish.Psychiatric genetics · 2016Article
- Heritability of complex white matter diffusion traits assessed in a population isolate.Human brain mapping · 2016Article
- GENLIB: an R package for the analysis of genealogical data.BMC bioinformatics · 2015Article
- Rare complement factor H variant associated with age-related macular degeneration in the Amish.Investigative ophthalmology & visual science · 2014Article
- Genome-wide patterns of identity-by-descent sharing in the French Canadian founder population.European journal of human genetics : EJHG · 2014Article
- Decreased bone mineral density in subjects carrying familial defective apolipoprotein B-100.The Journal of clinical endocrinology and metabolism · 2013Article
- Amish revisited: next-generation sequencing studies of psychiatric disorders among the Plain people.Trends in genetics : TIG · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundBecause they are a closed founder population, the Old Order Amish (OOA) of Lancaster County have been the subject of many medical genetics studies. We constructed four versions of Anabaptist Genealogy Database (AGDB) using three sources of genealogies and multiple updates. In addition, we developed PedHunter, a suite of query software that can solve pedigree-related problems automatically and systematically.
methodsWe report on how we have used new features in PedHunter to quantify the number and expected genetic contribution of founders to the OOA. The queries and utility of PedHunter programs are illustrated by examples using AGDB in this paper. For example, we calculated the number of founders expected to be contributing genetic material to the present-day living OOA and estimated the mean relative founder representation for each founder. New features in PedHunter also include pedigree trimming and pedigree renumbering, which should prove useful for studying large pedigrees.
resultsWith PedHunter version 2.0 querying AGDB version 4.0, we identified 34,160 presumed living OOA individuals and connected them into a 14-generation pedigree descending from 554 founders (332 females and 222 males) after trimming. From the analysis of cumulative mean relative founder representation, 128 founders (78 females and 50 males) accounted for over 95% of the mean relative founder contribution among living OOA descendants. DISCUSSION/
conclusionsThe OOA are a closed founder population in which a modest number of founders account for the genetic variation present in the current OOA population. Improvements to the PedHunter software will be useful in future studies of both the OOA and other populations with large and computerized genealogies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.